COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment

Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain...

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Autores principales: Muccioli, Lorenzo, Pensato, Umberto, Cani, Ilaria, Guerra, Luca, Provini, Federica, Bordin, Giorgio, Riccioli, Luca Albini, Lodi, Raffaele, Tinuper, Paolo, Bisulli, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513756/
https://www.ncbi.nlm.nih.gov/pubmed/33032013
http://dx.doi.org/10.1016/j.jneuroim.2020.577400
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author Muccioli, Lorenzo
Pensato, Umberto
Cani, Ilaria
Guerra, Luca
Provini, Federica
Bordin, Giorgio
Riccioli, Luca Albini
Lodi, Raffaele
Tinuper, Paolo
Bisulli, Francesca
author_facet Muccioli, Lorenzo
Pensato, Umberto
Cani, Ilaria
Guerra, Luca
Provini, Federica
Bordin, Giorgio
Riccioli, Luca Albini
Lodi, Raffaele
Tinuper, Paolo
Bisulli, Francesca
author_sort Muccioli, Lorenzo
collection PubMed
description Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain MRI and CSF analysis were unremarkable, while EEG showed slowing with frontal sharp waves. Neuropsychiatric symptoms resolved following treatment with tocilizumab. CNS involvement in COVID-19 may present as a subacute encephalopathy characterized by prominent frontal lobe dysfunction, with language disturbances as first neurological manifestation. Future studies should further investigate the role of tocilizumab in treating COVID-19-related encephalopathy.
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spelling pubmed-75137562020-09-25 COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment Muccioli, Lorenzo Pensato, Umberto Cani, Ilaria Guerra, Luca Provini, Federica Bordin, Giorgio Riccioli, Luca Albini Lodi, Raffaele Tinuper, Paolo Bisulli, Francesca J Neuroimmunol Short Communication Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain MRI and CSF analysis were unremarkable, while EEG showed slowing with frontal sharp waves. Neuropsychiatric symptoms resolved following treatment with tocilizumab. CNS involvement in COVID-19 may present as a subacute encephalopathy characterized by prominent frontal lobe dysfunction, with language disturbances as first neurological manifestation. Future studies should further investigate the role of tocilizumab in treating COVID-19-related encephalopathy. Elsevier B.V. 2020-12-15 2020-09-24 /pmc/articles/PMC7513756/ /pubmed/33032013 http://dx.doi.org/10.1016/j.jneuroim.2020.577400 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Muccioli, Lorenzo
Pensato, Umberto
Cani, Ilaria
Guerra, Luca
Provini, Federica
Bordin, Giorgio
Riccioli, Luca Albini
Lodi, Raffaele
Tinuper, Paolo
Bisulli, Francesca
COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title_full COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title_fullStr COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title_full_unstemmed COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title_short COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
title_sort covid-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513756/
https://www.ncbi.nlm.nih.gov/pubmed/33032013
http://dx.doi.org/10.1016/j.jneuroim.2020.577400
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