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Modern trends in downstream processing of biotherapeutics through continuous chromatography: The potential of Multicolumn Countercurrent Solvent Gradient Purification

Single-column (batch) preparative chromatography is the technique of choice for purification of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity trade-off, especially for separations containing a larger number of product-related impurities. This drawb...

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Detalles Bibliográficos
Autores principales:	De Luca, Chiara, Felletti, Simona, Lievore, Giulio, Chenet, Tatiana, Morbidelli, Massimo, Sponchioni, Mattia, Cavazzini, Alberto, Catani, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier B.V. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513800/ https://www.ncbi.nlm.nih.gov/pubmed/32994652 http://dx.doi.org/10.1016/j.trac.2020.116051

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