Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex h...

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Detalles Bibliográficos
Autores principales: Brandi, Maria Luisa, Giustina, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513816/
https://www.ncbi.nlm.nih.gov/pubmed/33082024
http://dx.doi.org/10.1016/j.tem.2020.09.003
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author Brandi, Maria Luisa
Giustina, Andrea
author_facet Brandi, Maria Luisa
Giustina, Andrea
author_sort Brandi, Maria Luisa
collection PubMed
description The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.
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spelling pubmed-75138162020-09-25 Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality Brandi, Maria Luisa Giustina, Andrea Trends Endocrinol Metab Review The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease. Published by Elsevier Ltd. 2020-12 2020-09-24 /pmc/articles/PMC7513816/ /pubmed/33082024 http://dx.doi.org/10.1016/j.tem.2020.09.003 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Brandi, Maria Luisa
Giustina, Andrea
Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title_full Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title_fullStr Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title_full_unstemmed Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title_short Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
title_sort sexual dimorphism of coronavirus 19 morbidity and lethality
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513816/
https://www.ncbi.nlm.nih.gov/pubmed/33082024
http://dx.doi.org/10.1016/j.tem.2020.09.003
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