The anti-cancer properties of heparin and its derivatives: a review and prospect

Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and i...

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Autores principales: Ma, Sai-Nan, Mao, Zhi-Xiang, Wu, Yang, Liang, Ming-Xing, Wang, Dan-Dan, Chen, Xiu, Chang, Ping-an, Zhang, Wei, Tang, Jin-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513850/
https://www.ncbi.nlm.nih.gov/pubmed/32538273
http://dx.doi.org/10.1080/19336918.2020.1767489
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author Ma, Sai-Nan
Mao, Zhi-Xiang
Wu, Yang
Liang, Ming-Xing
Wang, Dan-Dan
Chen, Xiu
Chang, Ping-an
Zhang, Wei
Tang, Jin-Hai
author_facet Ma, Sai-Nan
Mao, Zhi-Xiang
Wu, Yang
Liang, Ming-Xing
Wang, Dan-Dan
Chen, Xiu
Chang, Ping-an
Zhang, Wei
Tang, Jin-Hai
author_sort Ma, Sai-Nan
collection PubMed
description Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin’s role in inhibiting cancer progression, making it a promising anti-cancer agent.
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spelling pubmed-75138502020-10-01 The anti-cancer properties of heparin and its derivatives: a review and prospect Ma, Sai-Nan Mao, Zhi-Xiang Wu, Yang Liang, Ming-Xing Wang, Dan-Dan Chen, Xiu Chang, Ping-an Zhang, Wei Tang, Jin-Hai Cell Adh Migr Review Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin’s role in inhibiting cancer progression, making it a promising anti-cancer agent. Taylor & Francis 2020-06-14 /pmc/articles/PMC7513850/ /pubmed/32538273 http://dx.doi.org/10.1080/19336918.2020.1767489 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ma, Sai-Nan
Mao, Zhi-Xiang
Wu, Yang
Liang, Ming-Xing
Wang, Dan-Dan
Chen, Xiu
Chang, Ping-an
Zhang, Wei
Tang, Jin-Hai
The anti-cancer properties of heparin and its derivatives: a review and prospect
title The anti-cancer properties of heparin and its derivatives: a review and prospect
title_full The anti-cancer properties of heparin and its derivatives: a review and prospect
title_fullStr The anti-cancer properties of heparin and its derivatives: a review and prospect
title_full_unstemmed The anti-cancer properties of heparin and its derivatives: a review and prospect
title_short The anti-cancer properties of heparin and its derivatives: a review and prospect
title_sort anti-cancer properties of heparin and its derivatives: a review and prospect
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513850/
https://www.ncbi.nlm.nih.gov/pubmed/32538273
http://dx.doi.org/10.1080/19336918.2020.1767489
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