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Effects of durotomy versus myelotomy in the repair of spinal cord injury

Current management for spinal cord injury aims to reduce secondary damage and recover sensation and movement. Acute spinal cord injury is often accompanied by spinal cord compartment syndrome. Decompression by durotomy and/or myelotomy attempts to relieve secondary damage by completelyrelieving the...

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Autores principales: Telemacque, Dionne, Zhu, Feng-Zhao, Ren, Zheng-Wei, Chen, Kai-Fang, Drepaul, Deepak, Yao, Sheng, Yang, Fan, Qu, Yan-Zheng, Sun, Ting-Fang, Guo, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513969/
https://www.ncbi.nlm.nih.gov/pubmed/32246622
http://dx.doi.org/10.4103/1673-5374.280304
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author Telemacque, Dionne
Zhu, Feng-Zhao
Ren, Zheng-Wei
Chen, Kai-Fang
Drepaul, Deepak
Yao, Sheng
Yang, Fan
Qu, Yan-Zheng
Sun, Ting-Fang
Guo, Xiao-Dong
author_facet Telemacque, Dionne
Zhu, Feng-Zhao
Ren, Zheng-Wei
Chen, Kai-Fang
Drepaul, Deepak
Yao, Sheng
Yang, Fan
Qu, Yan-Zheng
Sun, Ting-Fang
Guo, Xiao-Dong
author_sort Telemacque, Dionne
collection PubMed
description Current management for spinal cord injury aims to reduce secondary damage and recover sensation and movement. Acute spinal cord injury is often accompanied by spinal cord compartment syndrome. Decompression by durotomy and/or myelotomy attempts to relieve secondary damage by completelyrelieving the compression of the spinal cord, removing the necrotic tissue, decreasing edema, reducing hemorrhage, and improving blood circulation in the spinal cord. However, it is controversial whether durotomy and/or myelotomy after spinal cord injury are beneficial to neurological recovery. This review compares the clinical effects of durotomy with those of myelotomy in the treatment of spinal cord injury. We found that durotomy has been performed more than myelotomy in the clinic, and that durotomy may be safer and more effective than myelotomy. Durotomy performed in humans had positive effects on neurological function in 92.3% of studies in this review, while durotomy in animals had positive effects on neurological function in 83.3% of studies. Myelotomy procedures were effective in 80% of animal studies, but only one clinical study of myelotomy has reported positive results, of motor and sensory improvement, in humans. However, a number of new animal studies have reported that durotomy and myelotomy are ineffective for spinal cord injury. More clinical data, in the form of a randomized controlled study, are needed to understand the effectiveness of durotomy and myelotomy.
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spelling pubmed-75139692020-10-07 Effects of durotomy versus myelotomy in the repair of spinal cord injury Telemacque, Dionne Zhu, Feng-Zhao Ren, Zheng-Wei Chen, Kai-Fang Drepaul, Deepak Yao, Sheng Yang, Fan Qu, Yan-Zheng Sun, Ting-Fang Guo, Xiao-Dong Neural Regen Res Review Current management for spinal cord injury aims to reduce secondary damage and recover sensation and movement. Acute spinal cord injury is often accompanied by spinal cord compartment syndrome. Decompression by durotomy and/or myelotomy attempts to relieve secondary damage by completelyrelieving the compression of the spinal cord, removing the necrotic tissue, decreasing edema, reducing hemorrhage, and improving blood circulation in the spinal cord. However, it is controversial whether durotomy and/or myelotomy after spinal cord injury are beneficial to neurological recovery. This review compares the clinical effects of durotomy with those of myelotomy in the treatment of spinal cord injury. We found that durotomy has been performed more than myelotomy in the clinic, and that durotomy may be safer and more effective than myelotomy. Durotomy performed in humans had positive effects on neurological function in 92.3% of studies in this review, while durotomy in animals had positive effects on neurological function in 83.3% of studies. Myelotomy procedures were effective in 80% of animal studies, but only one clinical study of myelotomy has reported positive results, of motor and sensory improvement, in humans. However, a number of new animal studies have reported that durotomy and myelotomy are ineffective for spinal cord injury. More clinical data, in the form of a randomized controlled study, are needed to understand the effectiveness of durotomy and myelotomy. Wolters Kluwer - Medknow 2020-04-03 /pmc/articles/PMC7513969/ /pubmed/32246622 http://dx.doi.org/10.4103/1673-5374.280304 Text en Copyright: © 2020 Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Telemacque, Dionne
Zhu, Feng-Zhao
Ren, Zheng-Wei
Chen, Kai-Fang
Drepaul, Deepak
Yao, Sheng
Yang, Fan
Qu, Yan-Zheng
Sun, Ting-Fang
Guo, Xiao-Dong
Effects of durotomy versus myelotomy in the repair of spinal cord injury
title Effects of durotomy versus myelotomy in the repair of spinal cord injury
title_full Effects of durotomy versus myelotomy in the repair of spinal cord injury
title_fullStr Effects of durotomy versus myelotomy in the repair of spinal cord injury
title_full_unstemmed Effects of durotomy versus myelotomy in the repair of spinal cord injury
title_short Effects of durotomy versus myelotomy in the repair of spinal cord injury
title_sort effects of durotomy versus myelotomy in the repair of spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513969/
https://www.ncbi.nlm.nih.gov/pubmed/32246622
http://dx.doi.org/10.4103/1673-5374.280304
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