Cargando…
Sensitive and reliable evaluation of single-cut sgRNAs to restore dystrophin by a GFP-reporter assay
Most Duchenne muscular dystrophy (DMD) cases are caused by deletions or duplications of one or more exons that disrupt the reading frame of DMD mRNA. Restoring the reading frame allows the production of partially functional dystrophin proteins, and result in less severe symptoms. Antisense oligonucl...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514106/ https://www.ncbi.nlm.nih.gov/pubmed/32970732 http://dx.doi.org/10.1371/journal.pone.0239468 |