Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity

Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these s...

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Detalles Bibliográficos
Autores principales: Pattison, Amanda M., Barton, Joshua R., Entezari, Ariana A., Zalewski, Alicja, Rappaport, Jeff A., Snook, Adam E., Waldman, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515455/
https://www.ncbi.nlm.nih.gov/pubmed/32594830
http://dx.doi.org/10.1080/15384047.2020.1779005

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