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Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment

Introduction Hepatorenal syndrome is the third most common cause of admissions among patients with liver cirrhosis and has a high mortality rate. It is a progressive deterioration of renal function in a patient with acute or chronic liver failure. The only definite curative treatment of choice for h...

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Autores principales: Fida, Samina, Khurshid, Syed Murtaza S, Mansoor, Hala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515548/
https://www.ncbi.nlm.nih.gov/pubmed/32983712
http://dx.doi.org/10.7759/cureus.10016
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author Fida, Samina
Khurshid, Syed Murtaza S
Mansoor, Hala
author_facet Fida, Samina
Khurshid, Syed Murtaza S
Mansoor, Hala
author_sort Fida, Samina
collection PubMed
description Introduction Hepatorenal syndrome is the third most common cause of admissions among patients with liver cirrhosis and has a high mortality rate. It is a progressive deterioration of renal function in a patient with acute or chronic liver failure. The only definite curative treatment of choice for hepatorenal syndrome is liver transplantation. This study aimed to determine the frequency of hepatorenal syndrome among patients with liver cirrhosis and to determine its outcome after treatment. Patients and Methods This case series prospective study was conducted at the Department of Medicine, CMH Lahore Medical College and Institute of Dentistry, Pakistan, from January 2019 to December 2019. The study included 136 patients of cirrhosis who were identified and worked up for hepatorenal syndrome. The patients with liver cirrhosis diagnosed as having hepatorenal syndrome were given treatment comprising injection terlipressin 2 mg four times a day and injection Haemaccel twice a day for two weeks, and after that the outcome was measured with a follow-up of six weeks. Results A total of 136 patients of cirrhosis were included in the study. Of the patients, 14 (10.3%) were diagnosed as suffering from hepatorenal syndrome. These diagnosed cases were given treatment for two weeks. Three (21.4%) of the patients having hepatorenal syndrome did not show any response, two (14.3%) patients recovered partially, four (28.6%) patients recovered fully, and four (28.6%) expired within one month of the treatment. One (7.14%) patient was referred during the treatment for liver transplant. Conclusions Hepatorenal syndrome is a common complication of cirrhosis. The treatment of systemic vasoconstrictors for hepatorenal syndrome proved to be effective in our study and should be the first priority for treating hepatorenal syndrome especially in places like Pakistan where liver transplantation is not that easily available.
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spelling pubmed-75155482020-09-26 Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment Fida, Samina Khurshid, Syed Murtaza S Mansoor, Hala Cureus Internal Medicine Introduction Hepatorenal syndrome is the third most common cause of admissions among patients with liver cirrhosis and has a high mortality rate. It is a progressive deterioration of renal function in a patient with acute or chronic liver failure. The only definite curative treatment of choice for hepatorenal syndrome is liver transplantation. This study aimed to determine the frequency of hepatorenal syndrome among patients with liver cirrhosis and to determine its outcome after treatment. Patients and Methods This case series prospective study was conducted at the Department of Medicine, CMH Lahore Medical College and Institute of Dentistry, Pakistan, from January 2019 to December 2019. The study included 136 patients of cirrhosis who were identified and worked up for hepatorenal syndrome. The patients with liver cirrhosis diagnosed as having hepatorenal syndrome were given treatment comprising injection terlipressin 2 mg four times a day and injection Haemaccel twice a day for two weeks, and after that the outcome was measured with a follow-up of six weeks. Results A total of 136 patients of cirrhosis were included in the study. Of the patients, 14 (10.3%) were diagnosed as suffering from hepatorenal syndrome. These diagnosed cases were given treatment for two weeks. Three (21.4%) of the patients having hepatorenal syndrome did not show any response, two (14.3%) patients recovered partially, four (28.6%) patients recovered fully, and four (28.6%) expired within one month of the treatment. One (7.14%) patient was referred during the treatment for liver transplant. Conclusions Hepatorenal syndrome is a common complication of cirrhosis. The treatment of systemic vasoconstrictors for hepatorenal syndrome proved to be effective in our study and should be the first priority for treating hepatorenal syndrome especially in places like Pakistan where liver transplantation is not that easily available. Cureus 2020-08-25 /pmc/articles/PMC7515548/ /pubmed/32983712 http://dx.doi.org/10.7759/cureus.10016 Text en Copyright © 2020, Fida et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Fida, Samina
Khurshid, Syed Murtaza S
Mansoor, Hala
Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title_full Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title_fullStr Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title_full_unstemmed Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title_short Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment
title_sort frequency of hepatorenal syndrome among patients with cirrhosis and outcome after treatment
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515548/
https://www.ncbi.nlm.nih.gov/pubmed/32983712
http://dx.doi.org/10.7759/cureus.10016
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