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Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sample a broad range of conformational space. We expect that the resulting dynamic arrangements of BRCA2 domains are...
Autores principales: | Sidhu, Arshdeep, Grosbart, Małgorzata, Sánchez, Humberto, Verhagen, Bram, van der Zon, Nick L L, Ristić, Dejan, van Rossum-Fikkert, Sarah E, Wyman, Claire |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515699/ https://www.ncbi.nlm.nih.gov/pubmed/32785644 http://dx.doi.org/10.1093/nar/gkaa648 |
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