Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity

Antisense oligonucleotide (ASO) drugs that trigger RNase H1 cleavage of target RNAs have been developed to treat various diseases. Basic pharmacological principles suggest that the development of tolerance is a common response to pharmacological interventions. In this manuscript, for the first time...

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Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Nichols, Joshua G, De Hoyos, Cheryl L, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515700/
https://www.ncbi.nlm.nih.gov/pubmed/32870273
http://dx.doi.org/10.1093/nar/gkaa715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515700/
https://www.ncbi.nlm.nih.gov/pubmed/32870273
http://dx.doi.org/10.1093/nar/gkaa715

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