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A Case of Lithium-Associated Hypocalciuric Hypercalcemia

Lithium is the treatment of choice for acute manic, mixed, and depressive episodes of bipolar disorder, along with long-term prophylaxis. A significant proportion of patients taking lithium develop lithium-associated hypercalcemia. Most cases are due to lithium-associated hyperparathyroidism with un...

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Autores principales: Nwabufor, Philip C, Omoniyi, Oluwamayowa N, Oyibo, Samson O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515745/
https://www.ncbi.nlm.nih.gov/pubmed/32983744
http://dx.doi.org/10.7759/cureus.10606
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author Nwabufor, Philip C
Omoniyi, Oluwamayowa N
Oyibo, Samson O
author_facet Nwabufor, Philip C
Omoniyi, Oluwamayowa N
Oyibo, Samson O
author_sort Nwabufor, Philip C
collection PubMed
description Lithium is the treatment of choice for acute manic, mixed, and depressive episodes of bipolar disorder, along with long-term prophylaxis. A significant proportion of patients taking lithium develop lithium-associated hypercalcemia. Most cases are due to lithium-associated hyperparathyroidism with underlying parathyroid adenoma or hyperplasia. We present a 67-year-old woman who presented with increasing lethargy and loss of concentration and was found to have slightly raised serum calcium levels with inappropriately low urinary calcium excretion levels characteristic of hypocalciuric hypercalcemia. She had been on lithium therapy for over 15 years for bipolar disease. She had no other cause for these findings and had no family history to suggest familial hypocalciuric hypercalcemia. Neck imaging ruled out any parathyroid adenoma or hyperplasia. A diagnosis of lithium-associated hypocalciuric hypercalcemia was discussed with the patient, and she remains stable under surveillance.
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spelling pubmed-75157452020-09-26 A Case of Lithium-Associated Hypocalciuric Hypercalcemia Nwabufor, Philip C Omoniyi, Oluwamayowa N Oyibo, Samson O Cureus Endocrinology/Diabetes/Metabolism Lithium is the treatment of choice for acute manic, mixed, and depressive episodes of bipolar disorder, along with long-term prophylaxis. A significant proportion of patients taking lithium develop lithium-associated hypercalcemia. Most cases are due to lithium-associated hyperparathyroidism with underlying parathyroid adenoma or hyperplasia. We present a 67-year-old woman who presented with increasing lethargy and loss of concentration and was found to have slightly raised serum calcium levels with inappropriately low urinary calcium excretion levels characteristic of hypocalciuric hypercalcemia. She had been on lithium therapy for over 15 years for bipolar disease. She had no other cause for these findings and had no family history to suggest familial hypocalciuric hypercalcemia. Neck imaging ruled out any parathyroid adenoma or hyperplasia. A diagnosis of lithium-associated hypocalciuric hypercalcemia was discussed with the patient, and she remains stable under surveillance. Cureus 2020-09-23 /pmc/articles/PMC7515745/ /pubmed/32983744 http://dx.doi.org/10.7759/cureus.10606 Text en Copyright © 2020, Nwabufor et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Nwabufor, Philip C
Omoniyi, Oluwamayowa N
Oyibo, Samson O
A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title_full A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title_fullStr A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title_full_unstemmed A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title_short A Case of Lithium-Associated Hypocalciuric Hypercalcemia
title_sort case of lithium-associated hypocalciuric hypercalcemia
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515745/
https://www.ncbi.nlm.nih.gov/pubmed/32983744
http://dx.doi.org/10.7759/cureus.10606
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