Cargando…
The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction
PURPOSE: To assess the effect of receiving a kidney with PUJ dysfunction on the recipient renal graft function. METHODOLOGY: 198 patients, who underwent renal transplantation from 1st January 2004 to 31st December 2014 in a single Center in the North West of England, were retrospectively reviewed us...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515856/ https://www.ncbi.nlm.nih.gov/pubmed/32524497 http://dx.doi.org/10.1007/s11255-020-02522-x |
_version_ | 1783586888210186240 |
---|---|
author | Tisljar, Miroslav Ali, Hatem Gledhill-Flynn, Charlie Garreus, Mila Ponnusamy, Arvind Ahmed, Aimun |
author_facet | Tisljar, Miroslav Ali, Hatem Gledhill-Flynn, Charlie Garreus, Mila Ponnusamy, Arvind Ahmed, Aimun |
author_sort | Tisljar, Miroslav |
collection | PubMed |
description | PURPOSE: To assess the effect of receiving a kidney with PUJ dysfunction on the recipient renal graft function. METHODOLOGY: 198 patients, who underwent renal transplantation from 1st January 2004 to 31st December 2014 in a single Center in the North West of England, were retrospectively reviewed using a computerized database. Split kidney function and the PUJ dysfunction for the donors were assessed using Tc-99 m MAG3 renogram. Each recipient with PUJ dysfunction was matched with a control recipient by age, gender, and number of days after transplantation. Both groups were followed up for 3.5 years post-transplantation. RESULTS: Of the 198 recipients included in the study, 19 recipients received kidneys from donors with PUJ dysfunction. Prevalence of PUJ dysfunction was 9.5% and it was more common in males than females. There was no difference between the case group and the control group in terms of age, gender, and follow-up time post-transplantation. There was also no difference between the case group and the control group in mean creatinine (130 µmol/l and 138 µmol/l respectively, p = 0.305) or the mean eGFR (48.6 ml/min and 47.5 ml/min respectively, p = 0.054) at 3.5 year post-kidney transplantation. CONCLUSION: This study showed that PUJ dysfunction of renal allograft has a negligible effect on graft function over 3.5 years period post-transplantation. A prospective randomized trial is needed to test these findings. In the presence of widened gap between demand and supply in renal transplantation, PUJ dysfunction in potential donors should not preclude them from donation. |
format | Online Article Text |
id | pubmed-7515856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-75158562020-10-07 The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction Tisljar, Miroslav Ali, Hatem Gledhill-Flynn, Charlie Garreus, Mila Ponnusamy, Arvind Ahmed, Aimun Int Urol Nephrol Urology - Original Paper PURPOSE: To assess the effect of receiving a kidney with PUJ dysfunction on the recipient renal graft function. METHODOLOGY: 198 patients, who underwent renal transplantation from 1st January 2004 to 31st December 2014 in a single Center in the North West of England, were retrospectively reviewed using a computerized database. Split kidney function and the PUJ dysfunction for the donors were assessed using Tc-99 m MAG3 renogram. Each recipient with PUJ dysfunction was matched with a control recipient by age, gender, and number of days after transplantation. Both groups were followed up for 3.5 years post-transplantation. RESULTS: Of the 198 recipients included in the study, 19 recipients received kidneys from donors with PUJ dysfunction. Prevalence of PUJ dysfunction was 9.5% and it was more common in males than females. There was no difference between the case group and the control group in terms of age, gender, and follow-up time post-transplantation. There was also no difference between the case group and the control group in mean creatinine (130 µmol/l and 138 µmol/l respectively, p = 0.305) or the mean eGFR (48.6 ml/min and 47.5 ml/min respectively, p = 0.054) at 3.5 year post-kidney transplantation. CONCLUSION: This study showed that PUJ dysfunction of renal allograft has a negligible effect on graft function over 3.5 years period post-transplantation. A prospective randomized trial is needed to test these findings. In the presence of widened gap between demand and supply in renal transplantation, PUJ dysfunction in potential donors should not preclude them from donation. Springer Netherlands 2020-06-10 2020 /pmc/articles/PMC7515856/ /pubmed/32524497 http://dx.doi.org/10.1007/s11255-020-02522-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Urology - Original Paper Tisljar, Miroslav Ali, Hatem Gledhill-Flynn, Charlie Garreus, Mila Ponnusamy, Arvind Ahmed, Aimun The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title | The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title_full | The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title_fullStr | The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title_full_unstemmed | The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title_short | The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
title_sort | outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction |
topic | Urology - Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515856/ https://www.ncbi.nlm.nih.gov/pubmed/32524497 http://dx.doi.org/10.1007/s11255-020-02522-x |
work_keys_str_mv | AT tisljarmiroslav theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT alihatem theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT gledhillflynncharlie theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT garreusmila theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT ponnusamyarvind theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT ahmedaimun theoutcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT tisljarmiroslav outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT alihatem outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT gledhillflynncharlie outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT garreusmila outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT ponnusamyarvind outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction AT ahmedaimun outcomeofkidneytransplantfromlivingdonorswithpelviuretericjunctiondysfunction |