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A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana
Parvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum (P. falciparum) has been controversially discussed. The study aimed to determine prevalence and severity of B19V infection, and the effect of co-infections on the risk for anaemia...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515863/ https://www.ncbi.nlm.nih.gov/pubmed/32973247 http://dx.doi.org/10.1038/s41598-020-72657-5 |
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author | Herr, Wiebke Krumkamp, Ralf Hogan, Benedikt Dekker, Denise Gyau, Kennedy Owusu-Dabo, Ellis Sarpong, Nimako Jaeger, Anna Loag, Wibke Winter, Doris Akenten, Charity Wiafe Eibach, Daniel Fickenscher, Helmut Eis-Hübinger, Anna May, Jürgen Kreuels, Benno |
author_facet | Herr, Wiebke Krumkamp, Ralf Hogan, Benedikt Dekker, Denise Gyau, Kennedy Owusu-Dabo, Ellis Sarpong, Nimako Jaeger, Anna Loag, Wibke Winter, Doris Akenten, Charity Wiafe Eibach, Daniel Fickenscher, Helmut Eis-Hübinger, Anna May, Jürgen Kreuels, Benno |
author_sort | Herr, Wiebke |
collection | PubMed |
description | Parvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum (P. falciparum) has been controversially discussed. The study aimed to determine prevalence and severity of B19V infection, and the effect of co-infections on the risk for anaemia. Between November 2013 and April 2015 a total of 1186 hospital visits of children with fever admitted to a hospital in Ghana were recorded. Malaria, B19V and additional diagnostics for fever causes were performed. Recent B19V infection was defined as PCR and/or IgM positivity. Risk factors for a B19V infection and for anaemia were analysed. The prevalence of anaemia was compared between children with/without B19V infection, stratified for the presence of malaria. B19V IgM/PCR was positive in 6.4% (n = 76; 40 IgM + , 30 PCR + , 6 IgM + and PCR +). Among the B19V cases 60.5% had a simultaneous P. falciparum infection. B19V IgM positivity but not PCR positivity was associated with moderate-severe anaemia (OR = 2.6; 95%-CI: 1.3–5.3; P < 0.01 vs. OR = 0.9; 95%-CI: 0.4–1.8; P = 0.70). P. falciparum and IgM positive B19V infection were independent risk factors for anaemia with no evidence of effect modification. Our data show a significant association between B19V infection, defined as IgM but not PCR positivity, and moderate-severe anaemia. A multiplicative effect of B19V and P. falciparum infection was not found. |
format | Online Article Text |
id | pubmed-7515863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75158632020-09-29 A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana Herr, Wiebke Krumkamp, Ralf Hogan, Benedikt Dekker, Denise Gyau, Kennedy Owusu-Dabo, Ellis Sarpong, Nimako Jaeger, Anna Loag, Wibke Winter, Doris Akenten, Charity Wiafe Eibach, Daniel Fickenscher, Helmut Eis-Hübinger, Anna May, Jürgen Kreuels, Benno Sci Rep Article Parvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum (P. falciparum) has been controversially discussed. The study aimed to determine prevalence and severity of B19V infection, and the effect of co-infections on the risk for anaemia. Between November 2013 and April 2015 a total of 1186 hospital visits of children with fever admitted to a hospital in Ghana were recorded. Malaria, B19V and additional diagnostics for fever causes were performed. Recent B19V infection was defined as PCR and/or IgM positivity. Risk factors for a B19V infection and for anaemia were analysed. The prevalence of anaemia was compared between children with/without B19V infection, stratified for the presence of malaria. B19V IgM/PCR was positive in 6.4% (n = 76; 40 IgM + , 30 PCR + , 6 IgM + and PCR +). Among the B19V cases 60.5% had a simultaneous P. falciparum infection. B19V IgM positivity but not PCR positivity was associated with moderate-severe anaemia (OR = 2.6; 95%-CI: 1.3–5.3; P < 0.01 vs. OR = 0.9; 95%-CI: 0.4–1.8; P = 0.70). P. falciparum and IgM positive B19V infection were independent risk factors for anaemia with no evidence of effect modification. Our data show a significant association between B19V infection, defined as IgM but not PCR positivity, and moderate-severe anaemia. A multiplicative effect of B19V and P. falciparum infection was not found. Nature Publishing Group UK 2020-09-24 /pmc/articles/PMC7515863/ /pubmed/32973247 http://dx.doi.org/10.1038/s41598-020-72657-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Herr, Wiebke Krumkamp, Ralf Hogan, Benedikt Dekker, Denise Gyau, Kennedy Owusu-Dabo, Ellis Sarpong, Nimako Jaeger, Anna Loag, Wibke Winter, Doris Akenten, Charity Wiafe Eibach, Daniel Fickenscher, Helmut Eis-Hübinger, Anna May, Jürgen Kreuels, Benno A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title | A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title_full | A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title_fullStr | A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title_full_unstemmed | A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title_short | A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana |
title_sort | cross-sectional study on risk factors for infection with parvovirus b19 and the association with anaemia in a febrile paediatric population in ghana |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515863/ https://www.ncbi.nlm.nih.gov/pubmed/32973247 http://dx.doi.org/10.1038/s41598-020-72657-5 |
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