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A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive pa...

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Autores principales: Robles-Pérez, A., Luburich, P., Bolivar, S., Dorca, J., Nolla, J. M., Molina-Molina, M., Narváez, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515904/
https://www.ncbi.nlm.nih.gov/pubmed/32973236
http://dx.doi.org/10.1038/s41598-020-72768-z
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author Robles-Pérez, A.
Luburich, P.
Bolivar, S.
Dorca, J.
Nolla, J. M.
Molina-Molina, M.
Narváez, J.
author_facet Robles-Pérez, A.
Luburich, P.
Bolivar, S.
Dorca, J.
Nolla, J. M.
Molina-Molina, M.
Narváez, J.
author_sort Robles-Pérez, A.
collection PubMed
description Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease.
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spelling pubmed-75159042020-09-29 A prospective study of lung disease in a cohort of early rheumatoid arthritis patients Robles-Pérez, A. Luburich, P. Bolivar, S. Dorca, J. Nolla, J. M. Molina-Molina, M. Narváez, J. Sci Rep Article Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease. Nature Publishing Group UK 2020-09-24 /pmc/articles/PMC7515904/ /pubmed/32973236 http://dx.doi.org/10.1038/s41598-020-72768-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Robles-Pérez, A.
Luburich, P.
Bolivar, S.
Dorca, J.
Nolla, J. M.
Molina-Molina, M.
Narváez, J.
A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_full A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_fullStr A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_full_unstemmed A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_short A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_sort prospective study of lung disease in a cohort of early rheumatoid arthritis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515904/
https://www.ncbi.nlm.nih.gov/pubmed/32973236
http://dx.doi.org/10.1038/s41598-020-72768-z
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