Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular dynamics (MD) simulations to characterize interactions of corneal keratan sulfate (KS), its desulfated form, as well as di-,...

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Detalles Bibliográficos
Autores principales: Miller, Michelle C., Cai, Chao, Wichapong, Kanin, Bhaduri, Sayantan, Pohl, Nicola L. B., Linhardt, Robert J., Gabius, Hans-Joachim, Mayo, Kevin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515912/
https://www.ncbi.nlm.nih.gov/pubmed/32973213
http://dx.doi.org/10.1038/s41598-020-72645-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515912/
https://www.ncbi.nlm.nih.gov/pubmed/32973213
http://dx.doi.org/10.1038/s41598-020-72645-9

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