Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival

Aquaporin 9 (AQP9) is an aquaglyceroporin that can transport lactate. Accumulating evidence suggests that astrocyte-to-neuron lactate shuttle (ANLS) plays a critical role in energy metabolism in neurons, including retinal ganglion cells (RGCs). To test the hypothesis that AQP9, in concert with monoc...

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Detalles Bibliográficos
Autores principales: Mori, Sotaro, Kurimoto, Takuji, Miki, Akiko, Maeda, Hidetaka, Kusuhara, Sentaro, Nakamura, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515957/
https://www.ncbi.nlm.nih.gov/pubmed/32748371
http://dx.doi.org/10.1007/s12035-020-02030-0

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