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Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums
The early loss of vision results in a reorganized neocortex, affecting areas of the brain that process both the spared and lost senses, and leads to heightened abilities on discrimination tasks involving the spared senses. Here, we used performance measures and machine learning algorithms that quant...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516066/ https://www.ncbi.nlm.nih.gov/pubmed/33083758 http://dx.doi.org/10.1016/j.isci.2020.101527 |
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author | Englund, Mackenzie Faridjoo, Samaan Iyer, Christopher S. Krubitzer, Leah |
author_facet | Englund, Mackenzie Faridjoo, Samaan Iyer, Christopher S. Krubitzer, Leah |
author_sort | Englund, Mackenzie |
collection | PubMed |
description | The early loss of vision results in a reorganized neocortex, affecting areas of the brain that process both the spared and lost senses, and leads to heightened abilities on discrimination tasks involving the spared senses. Here, we used performance measures and machine learning algorithms that quantify behavioral strategy to determine if and how early vision loss alters adaptive sensorimotor behavior. We tested opossums on a motor task involving somatosensation and found that early blind animals had increased limb placement accuracy compared with sighted controls, while showing similarities in crossing strategy. However, increased reliance on tactile inputs in early blind animals resulted in greater deficits in limb placement and behavioral flexibility when the whiskers were trimmed. These data show that compensatory cross-modal plasticity extends beyond sensory discrimination tasks to motor tasks involving the spared senses and highlights the importance of whiskers in guiding forelimb control. |
format | Online Article Text |
id | pubmed-7516066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75160662020-09-28 Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums Englund, Mackenzie Faridjoo, Samaan Iyer, Christopher S. Krubitzer, Leah iScience Article The early loss of vision results in a reorganized neocortex, affecting areas of the brain that process both the spared and lost senses, and leads to heightened abilities on discrimination tasks involving the spared senses. Here, we used performance measures and machine learning algorithms that quantify behavioral strategy to determine if and how early vision loss alters adaptive sensorimotor behavior. We tested opossums on a motor task involving somatosensation and found that early blind animals had increased limb placement accuracy compared with sighted controls, while showing similarities in crossing strategy. However, increased reliance on tactile inputs in early blind animals resulted in greater deficits in limb placement and behavioral flexibility when the whiskers were trimmed. These data show that compensatory cross-modal plasticity extends beyond sensory discrimination tasks to motor tasks involving the spared senses and highlights the importance of whiskers in guiding forelimb control. Elsevier 2020-09-03 /pmc/articles/PMC7516066/ /pubmed/33083758 http://dx.doi.org/10.1016/j.isci.2020.101527 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Englund, Mackenzie Faridjoo, Samaan Iyer, Christopher S. Krubitzer, Leah Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title | Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title_full | Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title_fullStr | Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title_full_unstemmed | Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title_short | Available Sensory Input Determines Motor Performance and Strategy in Early Blind and Sighted Short-Tailed Opossums |
title_sort | available sensory input determines motor performance and strategy in early blind and sighted short-tailed opossums |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516066/ https://www.ncbi.nlm.nih.gov/pubmed/33083758 http://dx.doi.org/10.1016/j.isci.2020.101527 |
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