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Redox Electrochemistry to Interrogate and Control Biomolecular Communication
Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516135/ https://www.ncbi.nlm.nih.gov/pubmed/33083771 http://dx.doi.org/10.1016/j.isci.2020.101545 |
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author | VanArsdale, Eric Pitzer, Juliana Payne, Gregory F. Bentley, William E. |
author_facet | VanArsdale, Eric Pitzer, Juliana Payne, Gregory F. Bentley, William E. |
author_sort | VanArsdale, Eric |
collection | PubMed |
description | Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are predictable, robust, and less context dependent. In turn, many transformative advances have resulted by the formal consideration of information transfer. One way to explore this potential for biological systems is to create bio-device interfaces that facilitate bidirectional information transfer between biology and electronics. Redox reactions enable this linkage because reduction and oxidation mediate communication within biology and can be coupled with electronics. By manipulating redox reactions, one is able to combine the programmable features of electronics with the ability to interrogate and modulate biological function. In this review, we examine methods to electrochemically interrogate the various components of molecular communication using redox chemistry and to electronically control cell communication using redox electrogenetics. |
format | Online Article Text |
id | pubmed-7516135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75161352020-09-28 Redox Electrochemistry to Interrogate and Control Biomolecular Communication VanArsdale, Eric Pitzer, Juliana Payne, Gregory F. Bentley, William E. iScience Review Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are predictable, robust, and less context dependent. In turn, many transformative advances have resulted by the formal consideration of information transfer. One way to explore this potential for biological systems is to create bio-device interfaces that facilitate bidirectional information transfer between biology and electronics. Redox reactions enable this linkage because reduction and oxidation mediate communication within biology and can be coupled with electronics. By manipulating redox reactions, one is able to combine the programmable features of electronics with the ability to interrogate and modulate biological function. In this review, we examine methods to electrochemically interrogate the various components of molecular communication using redox chemistry and to electronically control cell communication using redox electrogenetics. Elsevier 2020-09-08 /pmc/articles/PMC7516135/ /pubmed/33083771 http://dx.doi.org/10.1016/j.isci.2020.101545 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review VanArsdale, Eric Pitzer, Juliana Payne, Gregory F. Bentley, William E. Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title_full | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title_fullStr | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title_full_unstemmed | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title_short | Redox Electrochemistry to Interrogate and Control Biomolecular Communication |
title_sort | redox electrochemistry to interrogate and control biomolecular communication |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516135/ https://www.ncbi.nlm.nih.gov/pubmed/33083771 http://dx.doi.org/10.1016/j.isci.2020.101545 |
work_keys_str_mv | AT vanarsdaleeric redoxelectrochemistrytointerrogateandcontrolbiomolecularcommunication AT pitzerjuliana redoxelectrochemistrytointerrogateandcontrolbiomolecularcommunication AT paynegregoryf redoxelectrochemistrytointerrogateandcontrolbiomolecularcommunication AT bentleywilliame redoxelectrochemistrytointerrogateandcontrolbiomolecularcommunication |