The Botanical Drug PBI-05204, a Supercritical CO(2) Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties

Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-suppor...

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Detalles Bibliográficos
Autores principales: Colapietro, Alessandro, Yang, Peiying, Rossetti, Alessandra, Mancini, Andrea, Vitale, Flora, Martellucci, Stefano, Conway, Tara L., Chakraborty, Sharmistha, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Biordi, Assunta Leda, Wei, Daoyan, Newman, Robert A., Festuccia, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516200/
https://www.ncbi.nlm.nih.gov/pubmed/33013390
http://dx.doi.org/10.3389/fphar.2020.552428

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