Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)

A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sc...

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Detalles Bibliográficos
Autores principales: Sekiguchi, Yasunobu, Iizuka, Hiroko, Takizawa, Haruko, Sugimoto, Keiji, Sakajiri, Sakura, Inano, Tadaaki, Fukuda, Yasutaka, Shirane, Syuichi, Hamano, Yasuharu, Tomita, Shigeki, Izumi, Hiroshi, Okubo, Mitsuo, Nakamura, Noriko, Sawada, Tomohiro, Sekiguchi, Naoya, Noguchi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516310/
https://www.ncbi.nlm.nih.gov/pubmed/32461524
http://dx.doi.org/10.2169/internalmedicine.4417-20
Descripción
Sumario:A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sclerosis classic Hodgkin lymphoma (CHL-NS). She was considered to have “other iatrogenic immunodeficiency-associated lymphoproliferative disorders” (OIIA-LPD), MTX-associated Hodgkin lymphoma (MTX-HL). She received six courses of brentuximab vedotin (BV) in addition to AVD (BV+AVD). A complete metabolic response was obtained, and the RA went into remission. This is the fourth reported case of BV+AVD for MTX-HL.

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