Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)

A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sc...

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Autores principales: Sekiguchi, Yasunobu, Iizuka, Hiroko, Takizawa, Haruko, Sugimoto, Keiji, Sakajiri, Sakura, Inano, Tadaaki, Fukuda, Yasutaka, Shirane, Syuichi, Hamano, Yasuharu, Tomita, Shigeki, Izumi, Hiroshi, Okubo, Mitsuo, Nakamura, Noriko, Sawada, Tomohiro, Sekiguchi, Naoya, Noguchi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516310/
https://www.ncbi.nlm.nih.gov/pubmed/32461524
http://dx.doi.org/10.2169/internalmedicine.4417-20
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author Sekiguchi, Yasunobu
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Shirane, Syuichi
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Sekiguchi, Naoya
Noguchi, Masaaki
author_facet Sekiguchi, Yasunobu
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Shirane, Syuichi
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Sekiguchi, Naoya
Noguchi, Masaaki
author_sort Sekiguchi, Yasunobu
collection PubMed
description A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sclerosis classic Hodgkin lymphoma (CHL-NS). She was considered to have “other iatrogenic immunodeficiency-associated lymphoproliferative disorders” (OIIA-LPD), MTX-associated Hodgkin lymphoma (MTX-HL). She received six courses of brentuximab vedotin (BV) in addition to AVD (BV+AVD). A complete metabolic response was obtained, and the RA went into remission. This is the fourth reported case of BV+AVD for MTX-HL.
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spelling pubmed-75163102020-10-02 Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD) Sekiguchi, Yasunobu Iizuka, Hiroko Takizawa, Haruko Sugimoto, Keiji Sakajiri, Sakura Inano, Tadaaki Fukuda, Yasutaka Shirane, Syuichi Hamano, Yasuharu Tomita, Shigeki Izumi, Hiroshi Okubo, Mitsuo Nakamura, Noriko Sawada, Tomohiro Sekiguchi, Naoya Noguchi, Masaaki Intern Med Case Report A 53-year-old woman had been diagnosed with rheumatoid arthritis (RA) in X-6. She was started on methotrexate (MTX) in X-1. She developed a cough, and chest computed tomography showed abnormalities. In X, MTX was discontinued, but the cough persisted. A lung biopsy revealed a diagnosis of nodular sclerosis classic Hodgkin lymphoma (CHL-NS). She was considered to have “other iatrogenic immunodeficiency-associated lymphoproliferative disorders” (OIIA-LPD), MTX-associated Hodgkin lymphoma (MTX-HL). She received six courses of brentuximab vedotin (BV) in addition to AVD (BV+AVD). A complete metabolic response was obtained, and the RA went into remission. This is the fourth reported case of BV+AVD for MTX-HL. The Japanese Society of Internal Medicine 2020-05-26 2020-09-01 /pmc/articles/PMC7516310/ /pubmed/32461524 http://dx.doi.org/10.2169/internalmedicine.4417-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sekiguchi, Yasunobu
Iizuka, Hiroko
Takizawa, Haruko
Sugimoto, Keiji
Sakajiri, Sakura
Inano, Tadaaki
Fukuda, Yasutaka
Shirane, Syuichi
Hamano, Yasuharu
Tomita, Shigeki
Izumi, Hiroshi
Okubo, Mitsuo
Nakamura, Noriko
Sawada, Tomohiro
Sekiguchi, Naoya
Noguchi, Masaaki
Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title_full Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title_fullStr Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title_full_unstemmed Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title_short Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD)
title_sort methotrexate-associated hodgkin lymphoma in a patient with rheumatoid arthritis successfully treated with brentuximab vedotin in combination with doxorubicin, vinblastine, and dacarbazine (bv+avd)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516310/
https://www.ncbi.nlm.nih.gov/pubmed/32461524
http://dx.doi.org/10.2169/internalmedicine.4417-20
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