Synchronous Double Bile Duct Cancers with Distinct Genetic Features

A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar a...

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Autores principales: Morita, Shinichi, Suda, Takeshi, Kishi, Yoji, Iwasaki, Toshimitsu, Hiraoka, Nobuyoshi, Nagayama, Itsuo, Hoshi, Takahiro, Abe, Satoshi, Yagi, Kazuyoshi, Hasegawa, Go, Ikarashi, Toshihiko, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516326/
https://www.ncbi.nlm.nih.gov/pubmed/32493852
http://dx.doi.org/10.2169/internalmedicine.4613-20
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author Morita, Shinichi
Suda, Takeshi
Kishi, Yoji
Iwasaki, Toshimitsu
Hiraoka, Nobuyoshi
Nagayama, Itsuo
Hoshi, Takahiro
Abe, Satoshi
Yagi, Kazuyoshi
Hasegawa, Go
Ikarashi, Toshihiko
Terai, Shuji
author_facet Morita, Shinichi
Suda, Takeshi
Kishi, Yoji
Iwasaki, Toshimitsu
Hiraoka, Nobuyoshi
Nagayama, Itsuo
Hoshi, Takahiro
Abe, Satoshi
Yagi, Kazuyoshi
Hasegawa, Go
Ikarashi, Toshihiko
Terai, Shuji
author_sort Morita, Shinichi
collection PubMed
description A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar and distal lesions were moderately and poorly differentiated adenocarcinoma, respectively, and anatomically separated. Furthermore, the resected specimens showed no pancreaticobiliary maljunction. Histological and TP53 gene analyses in a rare case of synchronous double bile duct cancers suggest that there are various genetic pathways through which bile duct cancer develops, highlighting the complexity of its pathogenesis.
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spelling pubmed-75163262020-10-02 Synchronous Double Bile Duct Cancers with Distinct Genetic Features Morita, Shinichi Suda, Takeshi Kishi, Yoji Iwasaki, Toshimitsu Hiraoka, Nobuyoshi Nagayama, Itsuo Hoshi, Takahiro Abe, Satoshi Yagi, Kazuyoshi Hasegawa, Go Ikarashi, Toshihiko Terai, Shuji Intern Med Case Report A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar and distal lesions were moderately and poorly differentiated adenocarcinoma, respectively, and anatomically separated. Furthermore, the resected specimens showed no pancreaticobiliary maljunction. Histological and TP53 gene analyses in a rare case of synchronous double bile duct cancers suggest that there are various genetic pathways through which bile duct cancer develops, highlighting the complexity of its pathogenesis. The Japanese Society of Internal Medicine 2020-06-02 2020-09-01 /pmc/articles/PMC7516326/ /pubmed/32493852 http://dx.doi.org/10.2169/internalmedicine.4613-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Morita, Shinichi
Suda, Takeshi
Kishi, Yoji
Iwasaki, Toshimitsu
Hiraoka, Nobuyoshi
Nagayama, Itsuo
Hoshi, Takahiro
Abe, Satoshi
Yagi, Kazuyoshi
Hasegawa, Go
Ikarashi, Toshihiko
Terai, Shuji
Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title_full Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title_fullStr Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title_full_unstemmed Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title_short Synchronous Double Bile Duct Cancers with Distinct Genetic Features
title_sort synchronous double bile duct cancers with distinct genetic features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516326/
https://www.ncbi.nlm.nih.gov/pubmed/32493852
http://dx.doi.org/10.2169/internalmedicine.4613-20
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