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Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease
BACKGROUND AND AIMS: The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within enterocytes. METHODS: Here, in multiple, large cohorts of patients with inflammatory bowel disease (...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
by the AGA Institute
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516468/ https://www.ncbi.nlm.nih.gov/pubmed/32980345 http://dx.doi.org/10.1053/j.gastro.2020.09.029 |
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author | Suárez-Fariñas, Mayte Tokuyama, Minami Wei, Gabrielle Huang, Ruiqi Livanos, Alexandra Jha, Divya Levescot, Anais Irizar, Haritz Kosoy, Roman Cording, Sascha Wang, Wenhui Losic, Bojan Ungaro, Ryan C. Di’Narzo, Antonio Martinez-Delgado, Gustavo Suprun, Maria Corley, Michael J. Stojmirovic, Aleksandar Houten, Sander M. Peters, Lauren Curran, Mark Brodmerkel, Carrie Perrigoue, Jacqueline Friedman, Joshua R. Hao, Ke Schadt, Eric E. Zhu, Jun Ko, Huaibin M. Cho, Judy Dubinsky, Marla C. Sands, Bruce E. Ndhlovu, Lishomwa Cerf-Bensusan, Nadine Kasarskis, Andrew Colombel, Jean-Frederic Harpaz, Noam Argmann, Carmen Mehandru, Saurabh |
author_facet | Suárez-Fariñas, Mayte Tokuyama, Minami Wei, Gabrielle Huang, Ruiqi Livanos, Alexandra Jha, Divya Levescot, Anais Irizar, Haritz Kosoy, Roman Cording, Sascha Wang, Wenhui Losic, Bojan Ungaro, Ryan C. Di’Narzo, Antonio Martinez-Delgado, Gustavo Suprun, Maria Corley, Michael J. Stojmirovic, Aleksandar Houten, Sander M. Peters, Lauren Curran, Mark Brodmerkel, Carrie Perrigoue, Jacqueline Friedman, Joshua R. Hao, Ke Schadt, Eric E. Zhu, Jun Ko, Huaibin M. Cho, Judy Dubinsky, Marla C. Sands, Bruce E. Ndhlovu, Lishomwa Cerf-Bensusan, Nadine Kasarskis, Andrew Colombel, Jean-Frederic Harpaz, Noam Argmann, Carmen Mehandru, Saurabh |
author_sort | Suárez-Fariñas, Mayte |
collection | PubMed |
description | BACKGROUND AND AIMS: The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within enterocytes. METHODS: Here, in multiple, large cohorts of patients with inflammatory bowel disease (IBD), we have studied the intersections between Coronavirus Disease 2019 (COVID-19), intestinal inflammation, and IBD treatment. RESULTS: A striking expression of ACE2 on the small bowel enterocyte brush border supports intestinal infectivity by SARS-CoV-2. Commonly used IBD medications, both biologic and nonbiologic, do not significantly impact ACE2 and TMPRSS2 receptor expression in the uninflamed intestines. In addition, we have defined molecular responses to COVID-19 infection that are also enriched in IBD, pointing to shared molecular networks between COVID-19 and IBD. CONCLUSIONS: These data generate a novel appreciation of the confluence of COVID-19– and IBD-associated inflammation and provide mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19. Preprint doi: https://doi.org/10.1101/2020.05.21.109124 |
format | Online Article Text |
id | pubmed-7516468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | by the AGA Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-75164682020-09-25 Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease Suárez-Fariñas, Mayte Tokuyama, Minami Wei, Gabrielle Huang, Ruiqi Livanos, Alexandra Jha, Divya Levescot, Anais Irizar, Haritz Kosoy, Roman Cording, Sascha Wang, Wenhui Losic, Bojan Ungaro, Ryan C. Di’Narzo, Antonio Martinez-Delgado, Gustavo Suprun, Maria Corley, Michael J. Stojmirovic, Aleksandar Houten, Sander M. Peters, Lauren Curran, Mark Brodmerkel, Carrie Perrigoue, Jacqueline Friedman, Joshua R. Hao, Ke Schadt, Eric E. Zhu, Jun Ko, Huaibin M. Cho, Judy Dubinsky, Marla C. Sands, Bruce E. Ndhlovu, Lishomwa Cerf-Bensusan, Nadine Kasarskis, Andrew Colombel, Jean-Frederic Harpaz, Noam Argmann, Carmen Mehandru, Saurabh Gastroenterology Original Research BACKGROUND AND AIMS: The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within enterocytes. METHODS: Here, in multiple, large cohorts of patients with inflammatory bowel disease (IBD), we have studied the intersections between Coronavirus Disease 2019 (COVID-19), intestinal inflammation, and IBD treatment. RESULTS: A striking expression of ACE2 on the small bowel enterocyte brush border supports intestinal infectivity by SARS-CoV-2. Commonly used IBD medications, both biologic and nonbiologic, do not significantly impact ACE2 and TMPRSS2 receptor expression in the uninflamed intestines. In addition, we have defined molecular responses to COVID-19 infection that are also enriched in IBD, pointing to shared molecular networks between COVID-19 and IBD. CONCLUSIONS: These data generate a novel appreciation of the confluence of COVID-19– and IBD-associated inflammation and provide mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19. Preprint doi: https://doi.org/10.1101/2020.05.21.109124 by the AGA Institute 2021-01 2020-09-25 /pmc/articles/PMC7516468/ /pubmed/32980345 http://dx.doi.org/10.1053/j.gastro.2020.09.029 Text en © 2021 by the AGA Institute. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Research Suárez-Fariñas, Mayte Tokuyama, Minami Wei, Gabrielle Huang, Ruiqi Livanos, Alexandra Jha, Divya Levescot, Anais Irizar, Haritz Kosoy, Roman Cording, Sascha Wang, Wenhui Losic, Bojan Ungaro, Ryan C. Di’Narzo, Antonio Martinez-Delgado, Gustavo Suprun, Maria Corley, Michael J. Stojmirovic, Aleksandar Houten, Sander M. Peters, Lauren Curran, Mark Brodmerkel, Carrie Perrigoue, Jacqueline Friedman, Joshua R. Hao, Ke Schadt, Eric E. Zhu, Jun Ko, Huaibin M. Cho, Judy Dubinsky, Marla C. Sands, Bruce E. Ndhlovu, Lishomwa Cerf-Bensusan, Nadine Kasarskis, Andrew Colombel, Jean-Frederic Harpaz, Noam Argmann, Carmen Mehandru, Saurabh Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title | Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title_full | Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title_fullStr | Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title_full_unstemmed | Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title_short | Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease |
title_sort | intestinal inflammation modulates the expression of ace2 and tmprss2 and potentially overlaps with the pathogenesis of sars-cov-2–related disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516468/ https://www.ncbi.nlm.nih.gov/pubmed/32980345 http://dx.doi.org/10.1053/j.gastro.2020.09.029 |
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