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Allostery and Epistasis: Emergent Properties of Anisotropic Networks
Understanding the underlying mechanisms behind protein allostery and non-additivity of substitution outcomes (i.e., epistasis) is critical when attempting to predict the functional impact of mutations, particularly at non-conserved sites. In an effort to model these two biological properties, we ext...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517209/ https://www.ncbi.nlm.nih.gov/pubmed/33286439 http://dx.doi.org/10.3390/e22060667 |