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Melatonin prevents the binding of vascular endothelial growth factor to its receptor and promotes the expression of extracellular matrix-associated genes in nucleus pulposus cells

The mechanisms of intervertebral disc degeneration (IDD) involve numerous factors, including loss of the extracellular matrix (ECM) and vascular ingrowth. Melatonin has been reported to protect intervertebral discs (IVDs) from degeneration and to exert a potential anti-angiogenic effect. The aim of...

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Detalles Bibliográficos
Autores principales:	Shen, Chengchun, Li, Yan, Chen, Yunlin, Huang, Lei, Zhang, Feng, Wu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517348/ https://www.ncbi.nlm.nih.gov/pubmed/32989385 http://dx.doi.org/10.3892/etm.2020.9227

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