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Lithium chloride ameliorated spatial cognitive impairment through activating mTOR phosphorylation and inhibiting excessive autophagy in the repeated cerebral ischemia-reperfusion mouse model

Lithium has been previously demonstrated to alleviate cognitive impairment caused by neurodegenerative diseases and acute brain injuries; however, the specific mechanism remains elusive. In the present study, the C57BL/6 mouse model of spatial cognitive impairment induced by repeated cerebral ischem...

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Detalles Bibliográficos
Autores principales: Xiao, Yining, Fan, Mingyue, Jin, Wei, Li, William A., Jia, Yanqiu, Dong, Yanhong, Jiang, Xin, Xu, Jing, Meng, Nan, Lv, Peiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517419/
https://www.ncbi.nlm.nih.gov/pubmed/32989388
http://dx.doi.org/10.3892/etm.2020.9237