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Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma
Enlarged bone metastasis from renal cell carcinoma (RCC) can cause skeletal-related events, and thus treatment to inhibit the growth of bone metastases is often required. Although radiotherapy for RCC bone metastases can achieve a certain degree of local control, evidence is lacking regarding the ef...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517538/ https://www.ncbi.nlm.nih.gov/pubmed/32989401 http://dx.doi.org/10.3892/ol.2020.12130 |
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author | Negishi, Takahito Furubayashi, Nobuki Takamatsu, Dai Ieiri, Kousuke Nishiyama, Naotaka Kitamura, Hiroshi Nakamura, Motonobu |
author_facet | Negishi, Takahito Furubayashi, Nobuki Takamatsu, Dai Ieiri, Kousuke Nishiyama, Naotaka Kitamura, Hiroshi Nakamura, Motonobu |
author_sort | Negishi, Takahito |
collection | PubMed |
description | Enlarged bone metastasis from renal cell carcinoma (RCC) can cause skeletal-related events, and thus treatment to inhibit the growth of bone metastases is often required. Although radiotherapy for RCC bone metastases can achieve a certain degree of local control, evidence is lacking regarding the effects of systemic therapy to improve bone metastasis. The present study aimed to assess the treatment efficacy of targeted therapy and immune checkpoint inhibitors, and to determine whether systemic therapy without radiotherapy can shrink bone metastases of RCC. The present study retrospectively reviewed 44 patients with RCC with bone metastases treated via systemic therapy, including targeted therapy or immune checkpoint inhibitors. Patients were divided into two groups: Those who underwent systemic therapy with radiotherapy for bone lesions (n=29); and those who underwent systemic therapy without radiotherapy for bone lesions (n=15). The radiographical efficacy of systemic therapy and the time to progression of bone metastases were compared between groups. The overall response rate of systemic therapy with radiotherapy was 44%, and in total, 13 patients demonstrated a partial response. Only one patient (6%) had a partial response among those who were treated via systemic therapy without radiotherapy. The time to progression of bone metastasis was 9.5 and 2.1 months in patients treated with and without radiotherapy, respectively (P<0.0001). Collectively, the present results suggested that targeted therapy or immune checkpoint inhibitors without radiotherapy had only a slight effect on bone metastasis control. |
format | Online Article Text |
id | pubmed-7517538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-75175382020-09-27 Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma Negishi, Takahito Furubayashi, Nobuki Takamatsu, Dai Ieiri, Kousuke Nishiyama, Naotaka Kitamura, Hiroshi Nakamura, Motonobu Oncol Lett Articles Enlarged bone metastasis from renal cell carcinoma (RCC) can cause skeletal-related events, and thus treatment to inhibit the growth of bone metastases is often required. Although radiotherapy for RCC bone metastases can achieve a certain degree of local control, evidence is lacking regarding the effects of systemic therapy to improve bone metastasis. The present study aimed to assess the treatment efficacy of targeted therapy and immune checkpoint inhibitors, and to determine whether systemic therapy without radiotherapy can shrink bone metastases of RCC. The present study retrospectively reviewed 44 patients with RCC with bone metastases treated via systemic therapy, including targeted therapy or immune checkpoint inhibitors. Patients were divided into two groups: Those who underwent systemic therapy with radiotherapy for bone lesions (n=29); and those who underwent systemic therapy without radiotherapy for bone lesions (n=15). The radiographical efficacy of systemic therapy and the time to progression of bone metastases were compared between groups. The overall response rate of systemic therapy with radiotherapy was 44%, and in total, 13 patients demonstrated a partial response. Only one patient (6%) had a partial response among those who were treated via systemic therapy without radiotherapy. The time to progression of bone metastasis was 9.5 and 2.1 months in patients treated with and without radiotherapy, respectively (P<0.0001). Collectively, the present results suggested that targeted therapy or immune checkpoint inhibitors without radiotherapy had only a slight effect on bone metastasis control. D.A. Spandidos 2020-11 2020-09-21 /pmc/articles/PMC7517538/ /pubmed/32989401 http://dx.doi.org/10.3892/ol.2020.12130 Text en Copyright: © Negishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Negishi, Takahito Furubayashi, Nobuki Takamatsu, Dai Ieiri, Kousuke Nishiyama, Naotaka Kitamura, Hiroshi Nakamura, Motonobu Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title | Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title_full | Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title_fullStr | Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title_full_unstemmed | Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title_short | Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
title_sort | radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517538/ https://www.ncbi.nlm.nih.gov/pubmed/32989401 http://dx.doi.org/10.3892/ol.2020.12130 |
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