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Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study

BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born...

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Autores principales: Zaigham, Mehreen, Hellström-Westas, Lena, Domellöf, Magnus, Andersson, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517619/
https://www.ncbi.nlm.nih.gov/pubmed/32977763
http://dx.doi.org/10.1186/s12884-020-03253-8
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author Zaigham, Mehreen
Hellström-Westas, Lena
Domellöf, Magnus
Andersson, Ola
author_facet Zaigham, Mehreen
Hellström-Westas, Lena
Domellöf, Magnus
Andersson, Ola
author_sort Zaigham, Mehreen
collection PubMed
description BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants. METHODS: We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery. RESULTS: Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12 months. Prelabour caesarean infants (n = 66) had significantly lower Ages and Stages Questionnaire, second edition (ASQ-II) scores in all domains (communication, gross motor, fine motor, problem solving and personal-social) at 4 months of age with an adjusted mean difference (95% CI) of − 20.7 (− 28.7 to − 12.6) in ASQ-II total score as compared to vaginally born infants (n = 352). These differences remained for gross-motor skills at the 12 month assessment, adjusted mean difference (95% CI) -4.7 (− 8.8 to − 0.7), n = 62 and 336. CONCLUSIONS: Adverse neurodevelopmental outcomes in infants born by prelabour caesarean section may be apparent already a few months after birth. Additional studies are warranted to explore this relationship further.
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spelling pubmed-75176192020-09-25 Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study Zaigham, Mehreen Hellström-Westas, Lena Domellöf, Magnus Andersson, Ola BMC Pregnancy Childbirth Research Article BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants. METHODS: We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery. RESULTS: Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12 months. Prelabour caesarean infants (n = 66) had significantly lower Ages and Stages Questionnaire, second edition (ASQ-II) scores in all domains (communication, gross motor, fine motor, problem solving and personal-social) at 4 months of age with an adjusted mean difference (95% CI) of − 20.7 (− 28.7 to − 12.6) in ASQ-II total score as compared to vaginally born infants (n = 352). These differences remained for gross-motor skills at the 12 month assessment, adjusted mean difference (95% CI) -4.7 (− 8.8 to − 0.7), n = 62 and 336. CONCLUSIONS: Adverse neurodevelopmental outcomes in infants born by prelabour caesarean section may be apparent already a few months after birth. Additional studies are warranted to explore this relationship further. BioMed Central 2020-09-25 /pmc/articles/PMC7517619/ /pubmed/32977763 http://dx.doi.org/10.1186/s12884-020-03253-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zaigham, Mehreen
Hellström-Westas, Lena
Domellöf, Magnus
Andersson, Ola
Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title_full Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title_fullStr Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title_full_unstemmed Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title_short Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
title_sort prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517619/
https://www.ncbi.nlm.nih.gov/pubmed/32977763
http://dx.doi.org/10.1186/s12884-020-03253-8
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