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Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways

BACKGROUND: Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tumor patients at the molecular and multi-omics levels remain unclear. METHODS: O...

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Autores principales: Hu, Chao, Chen, Xiong, Yao, Chengyun, Liu, Yu, Xu, Haojun, Zhou, Guoren, Xia, Hongping, Xia, Jinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517824/
https://www.ncbi.nlm.nih.gov/pubmed/32999719
http://dx.doi.org/10.1186/s40170-020-00225-6
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author Hu, Chao
Chen, Xiong
Yao, Chengyun
Liu, Yu
Xu, Haojun
Zhou, Guoren
Xia, Hongping
Xia, Jinglin
author_facet Hu, Chao
Chen, Xiong
Yao, Chengyun
Liu, Yu
Xu, Haojun
Zhou, Guoren
Xia, Hongping
Xia, Jinglin
author_sort Hu, Chao
collection PubMed
description BACKGROUND: Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tumor patients at the molecular and multi-omics levels remain unclear. METHODS: Our study performed a comprehensive and multidimensional analysis in fourteen tumor types of The Cancer Genome Atlas (TCGA) and found body mass index (BMI)-related genes in multiple tumor types. Furthermore, we compared composite expression between normal, overweight, and obese patients of each immune cell subpopulation and metabolism gene subset. Statistical significance was calculated via the Kruskal-Wallis rank-sum test. RESULTS: Our analysis revealed that BMI-related genes are enriched in multiple tumor-related biological pathways involved in intracellular signaling, immune response, and metabolism. We also found the different relationships between BMI and different immune cell infiltration and metabolic pathway activity. Importantly, we found that many clinically actionable genes were BMI-affect genes. CONCLUSION: Overall, our data indicated that BMI-associated molecular characteristics involved in tumor immune and metabolic pathways, which may highlight the clinical importance of considering BMI-associated molecular signatures in cancer precision medicine.
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spelling pubmed-75178242020-09-29 Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways Hu, Chao Chen, Xiong Yao, Chengyun Liu, Yu Xu, Haojun Zhou, Guoren Xia, Hongping Xia, Jinglin Cancer Metab Research BACKGROUND: Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tumor patients at the molecular and multi-omics levels remain unclear. METHODS: Our study performed a comprehensive and multidimensional analysis in fourteen tumor types of The Cancer Genome Atlas (TCGA) and found body mass index (BMI)-related genes in multiple tumor types. Furthermore, we compared composite expression between normal, overweight, and obese patients of each immune cell subpopulation and metabolism gene subset. Statistical significance was calculated via the Kruskal-Wallis rank-sum test. RESULTS: Our analysis revealed that BMI-related genes are enriched in multiple tumor-related biological pathways involved in intracellular signaling, immune response, and metabolism. We also found the different relationships between BMI and different immune cell infiltration and metabolic pathway activity. Importantly, we found that many clinically actionable genes were BMI-affect genes. CONCLUSION: Overall, our data indicated that BMI-associated molecular characteristics involved in tumor immune and metabolic pathways, which may highlight the clinical importance of considering BMI-associated molecular signatures in cancer precision medicine. BioMed Central 2020-09-25 /pmc/articles/PMC7517824/ /pubmed/32999719 http://dx.doi.org/10.1186/s40170-020-00225-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hu, Chao
Chen, Xiong
Yao, Chengyun
Liu, Yu
Xu, Haojun
Zhou, Guoren
Xia, Hongping
Xia, Jinglin
Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title_full Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title_fullStr Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title_full_unstemmed Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title_short Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
title_sort body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517824/
https://www.ncbi.nlm.nih.gov/pubmed/32999719
http://dx.doi.org/10.1186/s40170-020-00225-6
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