Pharmacogenetics in Psychiatry: An Update on Clinical Usability

Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides...

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Autores principales: van Schaik, Ron H. N., Müller, Daniel J., Serretti, Alessandro, Ingelman-Sundberg, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518035/
https://www.ncbi.nlm.nih.gov/pubmed/33041820
http://dx.doi.org/10.3389/fphar.2020.575540
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author van Schaik, Ron H. N.
Müller, Daniel J.
Serretti, Alessandro
Ingelman-Sundberg, Magnus
author_facet van Schaik, Ron H. N.
Müller, Daniel J.
Serretti, Alessandro
Ingelman-Sundberg, Magnus
author_sort van Schaik, Ron H. N.
collection PubMed
description Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.
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spelling pubmed-75180352020-10-09 Pharmacogenetics in Psychiatry: An Update on Clinical Usability van Schaik, Ron H. N. Müller, Daniel J. Serretti, Alessandro Ingelman-Sundberg, Magnus Front Pharmacol Pharmacology Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics. Frontiers Media S.A. 2020-09-11 /pmc/articles/PMC7518035/ /pubmed/33041820 http://dx.doi.org/10.3389/fphar.2020.575540 Text en Copyright © 2020 van Schaik, Müller, Serretti and Ingelman-Sundberg http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
van Schaik, Ron H. N.
Müller, Daniel J.
Serretti, Alessandro
Ingelman-Sundberg, Magnus
Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title_full Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title_fullStr Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title_full_unstemmed Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title_short Pharmacogenetics in Psychiatry: An Update on Clinical Usability
title_sort pharmacogenetics in psychiatry: an update on clinical usability
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518035/
https://www.ncbi.nlm.nih.gov/pubmed/33041820
http://dx.doi.org/10.3389/fphar.2020.575540
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