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Molecular Mechanism and Approach in Progression of Meningioma
Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular si...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518150/ https://www.ncbi.nlm.nih.gov/pubmed/33042832 http://dx.doi.org/10.3389/fonc.2020.538845 |
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author | Shao, Zhiwei Liu, Lihong Zheng, Yanghao Tu, Sheng Pan, Yuanbo Yan, Sheng Wei, Qichun Shao, Anwen Zhang, Jianmin |
author_facet | Shao, Zhiwei Liu, Lihong Zheng, Yanghao Tu, Sheng Pan, Yuanbo Yan, Sheng Wei, Qichun Shao, Anwen Zhang, Jianmin |
author_sort | Shao, Zhiwei |
collection | PubMed |
description | Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular signals are closely related to the occurrence and development of malignancy in meningioma, which may provide the theoretical basis and potential direction for accurate and targeted treatment. We have reviewed advances in chromosomal variations and molecular mechanisms involved in the progression of meningioma, and have highlighted the association with malignant biological behavior including cell proliferation, angiogenesis, increased invasiveness, and inhibition of apoptosis. In addition, the chemotherapy of meningioma is summarized and discussed. |
format | Online Article Text |
id | pubmed-7518150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75181502020-10-09 Molecular Mechanism and Approach in Progression of Meningioma Shao, Zhiwei Liu, Lihong Zheng, Yanghao Tu, Sheng Pan, Yuanbo Yan, Sheng Wei, Qichun Shao, Anwen Zhang, Jianmin Front Oncol Oncology Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular signals are closely related to the occurrence and development of malignancy in meningioma, which may provide the theoretical basis and potential direction for accurate and targeted treatment. We have reviewed advances in chromosomal variations and molecular mechanisms involved in the progression of meningioma, and have highlighted the association with malignant biological behavior including cell proliferation, angiogenesis, increased invasiveness, and inhibition of apoptosis. In addition, the chemotherapy of meningioma is summarized and discussed. Frontiers Media S.A. 2020-09-11 /pmc/articles/PMC7518150/ /pubmed/33042832 http://dx.doi.org/10.3389/fonc.2020.538845 Text en Copyright © 2020 Shao, Liu, Zheng, Tu, Pan, Yan, Wei, Shao and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shao, Zhiwei Liu, Lihong Zheng, Yanghao Tu, Sheng Pan, Yuanbo Yan, Sheng Wei, Qichun Shao, Anwen Zhang, Jianmin Molecular Mechanism and Approach in Progression of Meningioma |
title | Molecular Mechanism and Approach in Progression of Meningioma |
title_full | Molecular Mechanism and Approach in Progression of Meningioma |
title_fullStr | Molecular Mechanism and Approach in Progression of Meningioma |
title_full_unstemmed | Molecular Mechanism and Approach in Progression of Meningioma |
title_short | Molecular Mechanism and Approach in Progression of Meningioma |
title_sort | molecular mechanism and approach in progression of meningioma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518150/ https://www.ncbi.nlm.nih.gov/pubmed/33042832 http://dx.doi.org/10.3389/fonc.2020.538845 |
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