Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections

We analyzed Clostridioides difficile infection (CDI) rates and various antimicrobials’ application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiot...

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Autores principales: Wendt, Sebastian, Ranft, Donald, Rodloff, Arne C, Lippmann, Norman, Lübbert, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518363/
https://www.ncbi.nlm.nih.gov/pubmed/33005693
http://dx.doi.org/10.1093/ofid/ofaa312
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author Wendt, Sebastian
Ranft, Donald
Rodloff, Arne C
Lippmann, Norman
Lübbert, Christoph
author_facet Wendt, Sebastian
Ranft, Donald
Rodloff, Arne C
Lippmann, Norman
Lübbert, Christoph
author_sort Wendt, Sebastian
collection PubMed
description We analyzed Clostridioides difficile infection (CDI) rates and various antimicrobials’ application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiotics’ specific pharmacokinetic and pharmacodynamic properties such as biliary excretion of ceftriaxone in its active form should be considered when determining their potential to cause CDI.
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spelling pubmed-75183632020-09-30 Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections Wendt, Sebastian Ranft, Donald Rodloff, Arne C Lippmann, Norman Lübbert, Christoph Open Forum Infect Dis Brief Reports We analyzed Clostridioides difficile infection (CDI) rates and various antimicrobials’ application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiotics’ specific pharmacokinetic and pharmacodynamic properties such as biliary excretion of ceftriaxone in its active form should be considered when determining their potential to cause CDI. Oxford University Press 2020-08-23 /pmc/articles/PMC7518363/ /pubmed/33005693 http://dx.doi.org/10.1093/ofid/ofaa312 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Wendt, Sebastian
Ranft, Donald
Rodloff, Arne C
Lippmann, Norman
Lübbert, Christoph
Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title_full Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title_fullStr Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title_full_unstemmed Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title_short Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections
title_sort switching from ceftriaxone to cefotaxime significantly contributes to reducing the burden of clostridioides difficile infections
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518363/
https://www.ncbi.nlm.nih.gov/pubmed/33005693
http://dx.doi.org/10.1093/ofid/ofaa312
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