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Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia

BACKGROUND: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO(2)−) respectively...

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Autores principales: Bourassa, Katelynn A., Postolache, Teodor T., Dagdag, Aline, Fuchs, Dietmar, Okusaga, Olaoluwa O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518413/
https://www.ncbi.nlm.nih.gov/pubmed/32982068
http://dx.doi.org/10.1515/pteridines-2020-0012
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author Bourassa, Katelynn A.
Postolache, Teodor T.
Dagdag, Aline
Fuchs, Dietmar
Okusaga, Olaoluwa O.
author_facet Bourassa, Katelynn A.
Postolache, Teodor T.
Dagdag, Aline
Fuchs, Dietmar
Okusaga, Olaoluwa O.
author_sort Bourassa, Katelynn A.
collection PubMed
description BACKGROUND: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO(2)−) respectively in overweight/obese adults with schizophrenia. METHODS: One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson’s and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO(2)− in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses). RESULTS: After controlling for potential confounders, sP-selectin positively correlated with triglycerides (r = 0.38, p = 0.01) and NO(2)− (r = 0.40, p < 0.01) in the overweight/obese group only. CONCLUSIONS: Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events).
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spelling pubmed-75184132020-09-25 Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia Bourassa, Katelynn A. Postolache, Teodor T. Dagdag, Aline Fuchs, Dietmar Okusaga, Olaoluwa O. Pteridines Article BACKGROUND: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO(2)−) respectively in overweight/obese adults with schizophrenia. METHODS: One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson’s and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO(2)− in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses). RESULTS: After controlling for potential confounders, sP-selectin positively correlated with triglycerides (r = 0.38, p = 0.01) and NO(2)− (r = 0.40, p < 0.01) in the overweight/obese group only. CONCLUSIONS: Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events). 2020-05-23 2020-01 /pmc/articles/PMC7518413/ /pubmed/32982068 http://dx.doi.org/10.1515/pteridines-2020-0012 Text en http://creativecommons.org/licenses/by/4.0/ This work is licensed under the Creative Commons Attribution alone 4.0 License.
spellingShingle Article
Bourassa, Katelynn A.
Postolache, Teodor T.
Dagdag, Aline
Fuchs, Dietmar
Okusaga, Olaoluwa O.
Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title_full Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title_fullStr Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title_full_unstemmed Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title_short Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
title_sort plasma soluble p-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518413/
https://www.ncbi.nlm.nih.gov/pubmed/32982068
http://dx.doi.org/10.1515/pteridines-2020-0012
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