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The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study

BACKGROUND/AIM: The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries. MATERIALS AND METHODS: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patien...

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Autores principales: KARACA, Ömer, PINAR, Hüseyin Ulaş, ÖZGÜR, Ahmet Fevzi, KULAKSIZOĞLU, Sevsen, DOĞAN, Rafi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518663/
https://www.ncbi.nlm.nih.gov/pubmed/31655508
http://dx.doi.org/10.3906/sag-1902-230
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author KARACA, Ömer
PINAR, Hüseyin Ulaş
ÖZGÜR, Ahmet Fevzi
KULAKSIZOĞLU, Sevsen
DOĞAN, Rafi
author_facet KARACA, Ömer
PINAR, Hüseyin Ulaş
ÖZGÜR, Ahmet Fevzi
KULAKSIZOĞLU, Sevsen
DOĞAN, Rafi
author_sort KARACA, Ömer
collection PubMed
description BACKGROUND/AIM: The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries. MATERIALS AND METHODS: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patients in Group P (pregabalin group, n = 27). A placebo was given to patients in Group C (control group, n = 27) at the same times. After combined spinal-epidural anesthesia was performed, venous blood samples were taken before tourniquet inflation (t(1)), just before tourniquet deflation (t(2)), and 20 min after tourniquet deflation (t(3)) for the analysis of total antioxidant status (TAS), total oxidant status (TOS), catalase (CAT), and ischemia-modified albumin (IMA). RESULTS: There was no significant difference in TAS levels between the groups for the t(3) period. However, the TAS in Group P was significantly higher in the t(3) period than the t(2) period (mean ± SD, 0.46 ± 0.1 vs. 0.38 ± 0.2 mmol of Trolox equivalent/L, respectively; P < 0.05). The CAT level in the t(3) period was significantly higher in Group P than Group C (mean ± SD, 53.04 ± 32.1 vs. 35.46 ± 17.2 µmol/formaldehyde, respectively; P < 0.05). In the t(3) period, the TOS was significantly lower in Group P than Group C (mean ± SD, 11.97 ± 5 vs. 18.29 ± 9.9 pg/mL, respectively; P < 0.05). The TOS in Group P was significantly lower in the t(3) period than the t(2) period (mean ± SD, 11.97 ± 5 vs. 18.98 ± 10.7 pg/mL, respectively; P < 0.0001). CONCLUSION: Pregabalin has no marked antioxidant activity, but it contributes to the antioxidant defense system of an organism.
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spelling pubmed-75186632020-09-28 The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study KARACA, Ömer PINAR, Hüseyin Ulaş ÖZGÜR, Ahmet Fevzi KULAKSIZOĞLU, Sevsen DOĞAN, Rafi Turk J Med Sci Article BACKGROUND/AIM: The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries. MATERIALS AND METHODS: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patients in Group P (pregabalin group, n = 27). A placebo was given to patients in Group C (control group, n = 27) at the same times. After combined spinal-epidural anesthesia was performed, venous blood samples were taken before tourniquet inflation (t(1)), just before tourniquet deflation (t(2)), and 20 min after tourniquet deflation (t(3)) for the analysis of total antioxidant status (TAS), total oxidant status (TOS), catalase (CAT), and ischemia-modified albumin (IMA). RESULTS: There was no significant difference in TAS levels between the groups for the t(3) period. However, the TAS in Group P was significantly higher in the t(3) period than the t(2) period (mean ± SD, 0.46 ± 0.1 vs. 0.38 ± 0.2 mmol of Trolox equivalent/L, respectively; P < 0.05). The CAT level in the t(3) period was significantly higher in Group P than Group C (mean ± SD, 53.04 ± 32.1 vs. 35.46 ± 17.2 µmol/formaldehyde, respectively; P < 0.05). In the t(3) period, the TOS was significantly lower in Group P than Group C (mean ± SD, 11.97 ± 5 vs. 18.29 ± 9.9 pg/mL, respectively; P < 0.05). The TOS in Group P was significantly lower in the t(3) period than the t(2) period (mean ± SD, 11.97 ± 5 vs. 18.98 ± 10.7 pg/mL, respectively; P < 0.0001). CONCLUSION: Pregabalin has no marked antioxidant activity, but it contributes to the antioxidant defense system of an organism. The Scientific and Technological Research Council of Turkey 2019-12-16 /pmc/articles/PMC7518663/ /pubmed/31655508 http://dx.doi.org/10.3906/sag-1902-230 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
KARACA, Ömer
PINAR, Hüseyin Ulaş
ÖZGÜR, Ahmet Fevzi
KULAKSIZOĞLU, Sevsen
DOĞAN, Rafi
The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title_full The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title_fullStr The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title_full_unstemmed The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title_short The effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
title_sort effect of pregabalin on tourniquet-induced ischemia-reperfusion injury:a prospective randomized study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518663/
https://www.ncbi.nlm.nih.gov/pubmed/31655508
http://dx.doi.org/10.3906/sag-1902-230
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