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An old friend: uric acid and its association with fractional flow reserve
BACKGROUND/AIM: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography. MATERIALS AND METHODS: W...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518665/ https://www.ncbi.nlm.nih.gov/pubmed/31655503 http://dx.doi.org/10.3906/sag-1903-91 |
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author | TOPAL, Salih SEZENÖZ, Burak CANDEMİR, Mustafa AÇIKGÖZ, Eser AÇIKGÖZ, Sadık Kadri BOYACI, Nuri Bülent |
author_facet | TOPAL, Salih SEZENÖZ, Burak CANDEMİR, Mustafa AÇIKGÖZ, Eser AÇIKGÖZ, Sadık Kadri BOYACI, Nuri Bülent |
author_sort | TOPAL, Salih |
collection | PubMed |
description | BACKGROUND/AIM: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography. MATERIALS AND METHODS: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of <0.80 (hemodynamically significant lesions), and Group 2 (n = 169) consisted of patients with FFR of >0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer. RESULTS: The mean UA level was significantly higher in patients whose FFR indicated hemodynamically significant coronary lesions (UA: 5.43 ± 1.29 mg/dL in Group 1 vs. 4.51 ± 1.34 mg/dL in Group 2, P < 0.001). CONCLUSION: Elevated UA levels are associated with hemodynamically significant coronary lesions measured with FFR. Uric acid may be used as a predictor of hemodynamically compromised coronary lesions before FFR procedures. |
format | Online Article Text |
id | pubmed-7518665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-75186652020-09-28 An old friend: uric acid and its association with fractional flow reserve TOPAL, Salih SEZENÖZ, Burak CANDEMİR, Mustafa AÇIKGÖZ, Eser AÇIKGÖZ, Sadık Kadri BOYACI, Nuri Bülent Turk J Med Sci Article BACKGROUND/AIM: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography. MATERIALS AND METHODS: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of <0.80 (hemodynamically significant lesions), and Group 2 (n = 169) consisted of patients with FFR of >0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer. RESULTS: The mean UA level was significantly higher in patients whose FFR indicated hemodynamically significant coronary lesions (UA: 5.43 ± 1.29 mg/dL in Group 1 vs. 4.51 ± 1.34 mg/dL in Group 2, P < 0.001). CONCLUSION: Elevated UA levels are associated with hemodynamically significant coronary lesions measured with FFR. Uric acid may be used as a predictor of hemodynamically compromised coronary lesions before FFR procedures. The Scientific and Technological Research Council of Turkey 2019-12-16 /pmc/articles/PMC7518665/ /pubmed/31655503 http://dx.doi.org/10.3906/sag-1903-91 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article TOPAL, Salih SEZENÖZ, Burak CANDEMİR, Mustafa AÇIKGÖZ, Eser AÇIKGÖZ, Sadık Kadri BOYACI, Nuri Bülent An old friend: uric acid and its association with fractional flow reserve |
title | An old friend: uric acid and its association with fractional flow reserve |
title_full | An old friend: uric acid and its association with fractional flow reserve |
title_fullStr | An old friend: uric acid and its association with fractional flow reserve |
title_full_unstemmed | An old friend: uric acid and its association with fractional flow reserve |
title_short | An old friend: uric acid and its association with fractional flow reserve |
title_sort | old friend: uric acid and its association with fractional flow reserve |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518665/ https://www.ncbi.nlm.nih.gov/pubmed/31655503 http://dx.doi.org/10.3906/sag-1903-91 |
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