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Clinical Profile of Covid-19 in Children, Review of Existing Literatures
WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, m...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518768/ https://www.ncbi.nlm.nih.gov/pubmed/33061744 http://dx.doi.org/10.2147/PHMT.S266063 |
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author | Tiruneh, Firew Tiyare |
author_facet | Tiruneh, Firew Tiyare |
author_sort | Tiruneh, Firew Tiyare |
collection | PubMed |
description | WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, manifestation and complication. The phylogenetic study showed that SARS-CoV-2 is a single-stranded RNA virus. The virus is very contagious and has rapidly spread globally. Its unique structure called S glycoproteins help the virus enters in and cause infection in the body. Children’s body reacts against SARS-CoV-2 infections through the involvement of innate and adaptive immune system. The clinical manifestation in children is not specific and not determined. However, fever and cough have mostly been profiled. Though the severe condition is rarely reported in children compared with adults, life-threatening complications, and death associated with COVID-19 disease have been documented. Underlying chronic pulmonary disease, cardiovascular disease, immunosuppression, and obesity significantly contribute to the complications. |
format | Online Article Text |
id | pubmed-7518768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75187682020-10-14 Clinical Profile of Covid-19 in Children, Review of Existing Literatures Tiruneh, Firew Tiyare Pediatric Health Med Ther Review WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, manifestation and complication. The phylogenetic study showed that SARS-CoV-2 is a single-stranded RNA virus. The virus is very contagious and has rapidly spread globally. Its unique structure called S glycoproteins help the virus enters in and cause infection in the body. Children’s body reacts against SARS-CoV-2 infections through the involvement of innate and adaptive immune system. The clinical manifestation in children is not specific and not determined. However, fever and cough have mostly been profiled. Though the severe condition is rarely reported in children compared with adults, life-threatening complications, and death associated with COVID-19 disease have been documented. Underlying chronic pulmonary disease, cardiovascular disease, immunosuppression, and obesity significantly contribute to the complications. Dove 2020-09-21 /pmc/articles/PMC7518768/ /pubmed/33061744 http://dx.doi.org/10.2147/PHMT.S266063 Text en © 2020 Tiruneh. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Tiruneh, Firew Tiyare Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title | Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title_full | Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title_fullStr | Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title_full_unstemmed | Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title_short | Clinical Profile of Covid-19 in Children, Review of Existing Literatures |
title_sort | clinical profile of covid-19 in children, review of existing literatures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518768/ https://www.ncbi.nlm.nih.gov/pubmed/33061744 http://dx.doi.org/10.2147/PHMT.S266063 |
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