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Clinical Profile of Covid-19 in Children, Review of Existing Literatures

WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, m...

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Autor principal: Tiruneh, Firew Tiyare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518768/
https://www.ncbi.nlm.nih.gov/pubmed/33061744
http://dx.doi.org/10.2147/PHMT.S266063
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author Tiruneh, Firew Tiyare
author_facet Tiruneh, Firew Tiyare
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description WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, manifestation and complication. The phylogenetic study showed that SARS-CoV-2 is a single-stranded RNA virus. The virus is very contagious and has rapidly spread globally. Its unique structure called S glycoproteins help the virus enters in and cause infection in the body. Children’s body reacts against SARS-CoV-2 infections through the involvement of innate and adaptive immune system. The clinical manifestation in children is not specific and not determined. However, fever and cough have mostly been profiled. Though the severe condition is rarely reported in children compared with adults, life-threatening complications, and death associated with COVID-19 disease have been documented. Underlying chronic pulmonary disease, cardiovascular disease, immunosuppression, and obesity significantly contribute to the complications.
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spelling pubmed-75187682020-10-14 Clinical Profile of Covid-19 in Children, Review of Existing Literatures Tiruneh, Firew Tiyare Pediatric Health Med Ther Review WHO has confirmed that COVID-19 disease is a pandemic on March 11, 2020. The disease is caused by a new virus called SARS-CoV-2. Since, the pandemic was announced around 18,854,287 cases and 708,639 deaths were reported as of August 7, 2020. This review aimed to explore the etiology, pathogenesis, manifestation and complication. The phylogenetic study showed that SARS-CoV-2 is a single-stranded RNA virus. The virus is very contagious and has rapidly spread globally. Its unique structure called S glycoproteins help the virus enters in and cause infection in the body. Children’s body reacts against SARS-CoV-2 infections through the involvement of innate and adaptive immune system. The clinical manifestation in children is not specific and not determined. However, fever and cough have mostly been profiled. Though the severe condition is rarely reported in children compared with adults, life-threatening complications, and death associated with COVID-19 disease have been documented. Underlying chronic pulmonary disease, cardiovascular disease, immunosuppression, and obesity significantly contribute to the complications. Dove 2020-09-21 /pmc/articles/PMC7518768/ /pubmed/33061744 http://dx.doi.org/10.2147/PHMT.S266063 Text en © 2020 Tiruneh. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tiruneh, Firew Tiyare
Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title_full Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title_fullStr Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title_full_unstemmed Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title_short Clinical Profile of Covid-19 in Children, Review of Existing Literatures
title_sort clinical profile of covid-19 in children, review of existing literatures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518768/
https://www.ncbi.nlm.nih.gov/pubmed/33061744
http://dx.doi.org/10.2147/PHMT.S266063
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