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Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus
OBJECTIVE: To determine the toxicity and efficacy of radiotherapy for cervical cancer in patients with systemic lupus erythematosus (SLE). METHODS: Medical records of patients with SLE who received radiation for cervical cancer from January 2011 to January 2019 were reviewed. For definitive radiothe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518778/ https://www.ncbi.nlm.nih.gov/pubmed/33061566 http://dx.doi.org/10.2147/CMAR.S264795 |
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author | Ma, Jiabin Wang, Weiping Shen, Jing Hou, Xiaorong Lian, Xin Yan, Junfang Sun, Shuai Miao, Zheng Meng, Qingyu Hu, Ke Zhang, Fuquan |
author_facet | Ma, Jiabin Wang, Weiping Shen, Jing Hou, Xiaorong Lian, Xin Yan, Junfang Sun, Shuai Miao, Zheng Meng, Qingyu Hu, Ke Zhang, Fuquan |
author_sort | Ma, Jiabin |
collection | PubMed |
description | OBJECTIVE: To determine the toxicity and efficacy of radiotherapy for cervical cancer in patients with systemic lupus erythematosus (SLE). METHODS: Medical records of patients with SLE who received radiation for cervical cancer from January 2011 to January 2019 were reviewed. For definitive radiotherapy, a dose of 50.4 Gy in 28 fractions was delivered by intensity-modulated radiation therapy (IMRT) combined with high-dose-rate brachytherapy of 28 to 30 Gy in 5 fractions. A dose of 45 to 50.4 Gy in 25–28 fractions was delivered for postoperative radiation. All patients were in remission with or without a low dosage of prednisone or immunosuppressive medication. Survival data were analyzed with the Kaplan–Meier method. The incidence of severe toxicities among patients was compared with the chi-square test or Fisher’s exact test. RESULTS: Twelve patients with SLE were included in this study. Definitive radiotherapy was delivered in 7 patients with FIGO (2009) stage II–III disease. Five patients with FIGO I disease received postoperative radiation. The median follow-up time was 22.1 months. The 3-year overall survival (OS) and 3-year progression-free survival (PFS) were 77.8% and 83.3%, respectively. One patient of definitive radiotherapy and one patient of postoperative radiation died due to distant metastasis of cervical cancer. Grade 3 or higher acute and chronic reactions occurred in 58.3% and 8.3% patients, respectively. Acute grade 3 or higher toxicity correlated with the presence of chemotherapy (p = 0.045). CONCLUSION: Modern radiotherapy for cervical cancer was well tolerated in SLE patients with remission and provided a favorable outcome. |
format | Online Article Text |
id | pubmed-7518778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75187782020-10-14 Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus Ma, Jiabin Wang, Weiping Shen, Jing Hou, Xiaorong Lian, Xin Yan, Junfang Sun, Shuai Miao, Zheng Meng, Qingyu Hu, Ke Zhang, Fuquan Cancer Manag Res Original Research OBJECTIVE: To determine the toxicity and efficacy of radiotherapy for cervical cancer in patients with systemic lupus erythematosus (SLE). METHODS: Medical records of patients with SLE who received radiation for cervical cancer from January 2011 to January 2019 were reviewed. For definitive radiotherapy, a dose of 50.4 Gy in 28 fractions was delivered by intensity-modulated radiation therapy (IMRT) combined with high-dose-rate brachytherapy of 28 to 30 Gy in 5 fractions. A dose of 45 to 50.4 Gy in 25–28 fractions was delivered for postoperative radiation. All patients were in remission with or without a low dosage of prednisone or immunosuppressive medication. Survival data were analyzed with the Kaplan–Meier method. The incidence of severe toxicities among patients was compared with the chi-square test or Fisher’s exact test. RESULTS: Twelve patients with SLE were included in this study. Definitive radiotherapy was delivered in 7 patients with FIGO (2009) stage II–III disease. Five patients with FIGO I disease received postoperative radiation. The median follow-up time was 22.1 months. The 3-year overall survival (OS) and 3-year progression-free survival (PFS) were 77.8% and 83.3%, respectively. One patient of definitive radiotherapy and one patient of postoperative radiation died due to distant metastasis of cervical cancer. Grade 3 or higher acute and chronic reactions occurred in 58.3% and 8.3% patients, respectively. Acute grade 3 or higher toxicity correlated with the presence of chemotherapy (p = 0.045). CONCLUSION: Modern radiotherapy for cervical cancer was well tolerated in SLE patients with remission and provided a favorable outcome. Dove 2020-09-21 /pmc/articles/PMC7518778/ /pubmed/33061566 http://dx.doi.org/10.2147/CMAR.S264795 Text en © 2020 Ma et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Ma, Jiabin Wang, Weiping Shen, Jing Hou, Xiaorong Lian, Xin Yan, Junfang Sun, Shuai Miao, Zheng Meng, Qingyu Hu, Ke Zhang, Fuquan Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title | Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title_full | Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title_fullStr | Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title_full_unstemmed | Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title_short | Radiotherapy for Cervical Cancer in Patients with Systemic Lupus Erythematosus |
title_sort | radiotherapy for cervical cancer in patients with systemic lupus erythematosus |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518778/ https://www.ncbi.nlm.nih.gov/pubmed/33061566 http://dx.doi.org/10.2147/CMAR.S264795 |
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