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Near-infrared light-triggered NO release for spinal cord injury repair
Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518874/ https://www.ncbi.nlm.nih.gov/pubmed/32978153 http://dx.doi.org/10.1126/sciadv.abc3513 |
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author | Jiang, Yaqin Fu, Pengfei Liu, Yanyan Wang, Chaochao Zhao, Peiran Chu, Xu Jiang, Xingwu Yang, Wei Wu, Yelin Wang, Ya Xu, Guohua Hu, Jin Bu, Wenbo |
author_facet | Jiang, Yaqin Fu, Pengfei Liu, Yanyan Wang, Chaochao Zhao, Peiran Chu, Xu Jiang, Xingwu Yang, Wei Wu, Yelin Wang, Ya Xu, Guohua Hu, Jin Bu, Wenbo |
author_sort | Jiang, Yaqin |
collection | PubMed |
description | Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a single function. Here, we suggest a “pleiotropic messenger” strategy based on near-infrared (NIR)–triggered on-demand NO release at the lesion area for traumatic SCI recovery via the concurrent neuroregeneration and neuroprotection processing. This NO delivery system was constructed as upconversion nanoparticle (UCNP) core coated by zeolitic imidazolate framework–8 (ZIF-8) with NO donor (CysNO). This combined strategy substantial promotes the repair of SCI in vertebrates, ascribable to the pleiotropic effects of NO including the suppression of gliosis and inflammation, the promotion of neuroregeneration, and the protection of neurons from apoptosis, which opens intriguing perspectives not only in nerve repair but also in neurological research and tissue engineering. |
format | Online Article Text |
id | pubmed-7518874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75188742020-10-02 Near-infrared light-triggered NO release for spinal cord injury repair Jiang, Yaqin Fu, Pengfei Liu, Yanyan Wang, Chaochao Zhao, Peiran Chu, Xu Jiang, Xingwu Yang, Wei Wu, Yelin Wang, Ya Xu, Guohua Hu, Jin Bu, Wenbo Sci Adv Research Articles Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a single function. Here, we suggest a “pleiotropic messenger” strategy based on near-infrared (NIR)–triggered on-demand NO release at the lesion area for traumatic SCI recovery via the concurrent neuroregeneration and neuroprotection processing. This NO delivery system was constructed as upconversion nanoparticle (UCNP) core coated by zeolitic imidazolate framework–8 (ZIF-8) with NO donor (CysNO). This combined strategy substantial promotes the repair of SCI in vertebrates, ascribable to the pleiotropic effects of NO including the suppression of gliosis and inflammation, the promotion of neuroregeneration, and the protection of neurons from apoptosis, which opens intriguing perspectives not only in nerve repair but also in neurological research and tissue engineering. American Association for the Advancement of Science 2020-09-25 /pmc/articles/PMC7518874/ /pubmed/32978153 http://dx.doi.org/10.1126/sciadv.abc3513 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Jiang, Yaqin Fu, Pengfei Liu, Yanyan Wang, Chaochao Zhao, Peiran Chu, Xu Jiang, Xingwu Yang, Wei Wu, Yelin Wang, Ya Xu, Guohua Hu, Jin Bu, Wenbo Near-infrared light-triggered NO release for spinal cord injury repair |
title | Near-infrared light-triggered NO release for spinal cord injury repair |
title_full | Near-infrared light-triggered NO release for spinal cord injury repair |
title_fullStr | Near-infrared light-triggered NO release for spinal cord injury repair |
title_full_unstemmed | Near-infrared light-triggered NO release for spinal cord injury repair |
title_short | Near-infrared light-triggered NO release for spinal cord injury repair |
title_sort | near-infrared light-triggered no release for spinal cord injury repair |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518874/ https://www.ncbi.nlm.nih.gov/pubmed/32978153 http://dx.doi.org/10.1126/sciadv.abc3513 |
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