Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show...

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Detalles Bibliográficos
Autores principales: Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518889/
https://www.ncbi.nlm.nih.gov/pubmed/32902381
http://dx.doi.org/10.7554/eLife.61090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518889/
https://www.ncbi.nlm.nih.gov/pubmed/32902381
http://dx.doi.org/10.7554/eLife.61090

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