Cargando…
Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show...
Autores principales: | Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518889/ https://www.ncbi.nlm.nih.gov/pubmed/32902381 http://dx.doi.org/10.7554/eLife.61090 |
Ejemplares similares
-
The H3.3K27M oncohistone antagonizes reprogramming in Drosophila
por: Ahmad, Kami, et al.
Publicado: (2021) -
Improved CUT&RUN chromatin profiling tools
por: Meers, Michael P, et al.
Publicado: (2019) -
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation
por: Henikoff, Steven, et al.
Publicado: (2020) -
Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs
por: Janssens, Derek H., et al.
Publicado: (2018) -
Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia
por: Janssens, Derek H., et al.
Publicado: (2021)