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Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518979/ https://www.ncbi.nlm.nih.gov/pubmed/32661647 http://dx.doi.org/10.1007/s15010-020-01475-8 |
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| author | Coste, A. T. Kritikos, A. Li, J. Khanna, N. Goldenberger, D. Garzoni, C. Zehnder, C. Boggian, K. Neofytos, D. Riat, A. Bachmann, D. Sanglard, D. Lamoth, F. |
| author_facet | Coste, A. T. Kritikos, A. Li, J. Khanna, N. Goldenberger, D. Garzoni, C. Zehnder, C. Boggian, K. Neofytos, D. Riat, A. Bachmann, D. Sanglard, D. Lamoth, F. |
| author_sort | Coste, A. T. |
| collection | PubMed |
| description | Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15–77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%. |
| format | Online Article Text |
| id | pubmed-7518979 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75189792020-10-13 Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland Coste, A. T. Kritikos, A. Li, J. Khanna, N. Goldenberger, D. Garzoni, C. Zehnder, C. Boggian, K. Neofytos, D. Riat, A. Bachmann, D. Sanglard, D. Lamoth, F. Infection Brief Report Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15–77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%. Springer Berlin Heidelberg 2020-07-13 2020 /pmc/articles/PMC7518979/ /pubmed/32661647 http://dx.doi.org/10.1007/s15010-020-01475-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Brief Report Coste, A. T. Kritikos, A. Li, J. Khanna, N. Goldenberger, D. Garzoni, C. Zehnder, C. Boggian, K. Neofytos, D. Riat, A. Bachmann, D. Sanglard, D. Lamoth, F. Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title | Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title_full | Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title_fullStr | Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title_full_unstemmed | Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title_short | Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland |
| title_sort | emerging echinocandin-resistant candida albicans and glabrata in switzerland |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518979/ https://www.ncbi.nlm.nih.gov/pubmed/32661647 http://dx.doi.org/10.1007/s15010-020-01475-8 |
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