Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models

The etiology of CNS diseases including multiple sclerosis, Parkinson’s disease and amyotrophic lateral sclerosis remains elusive despite decades of research resulting in treatments with only symptomatic effects. In this study, we provide evidence that a metabolic shift from glucose to lipid is a key...

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Detalles Bibliográficos
Autores principales: Trabjerg, Michael Sloth, Mørkholt, Anne Skøttrup, Lichota, Jacek, Oklinski, Michal Krystian Egelund, Andersen, Dennis Christian, Jønsson, Katrine, Mørk, Kasper, Skjønnemand, Marie-Louise Nibelius, Kroese, Lona John, Pritchard, Colin Eliot Jason, Huijbers, Ivo Johan, Gazerani, Parisa, Corthals, Angelique, Nieland, John Dirk Vestergaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519132/
https://www.ncbi.nlm.nih.gov/pubmed/32973137
http://dx.doi.org/10.1038/s41598-020-72638-8

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