The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models

Small ubiquitin-like modifier (SUMO) is a widespread regulatory mechanism of post-translational modification (PTM) that induces rapid and reversible changes in protein function and stability. Using SUMO conjugase Ubc9-overexpressing or knock-down cells in Parkinson’s disease (PD) models, we demonstr...

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Detalles Bibliográficos
Autores principales: Verma, Dinesh Kumar, Ghosh, Anurupa, Ruggiero, Lindsey, Cartier, Etienne, Janezic, Eric, Williams, Dionne, Jung, Eui-Gil, Moore, Michael, Seo, Jong Bok, Kim, Yong-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519168/
https://www.ncbi.nlm.nih.gov/pubmed/32887693
http://dx.doi.org/10.1523/ENEURO.0134-20.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519168/
https://www.ncbi.nlm.nih.gov/pubmed/32887693
http://dx.doi.org/10.1523/ENEURO.0134-20.2020

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