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The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models
Small ubiquitin-like modifier (SUMO) is a widespread regulatory mechanism of post-translational modification (PTM) that induces rapid and reversible changes in protein function and stability. Using SUMO conjugase Ubc9-overexpressing or knock-down cells in Parkinson’s disease (PD) models, we demonstr...
Autores principales: | Verma, Dinesh Kumar, Ghosh, Anurupa, Ruggiero, Lindsey, Cartier, Etienne, Janezic, Eric, Williams, Dionne, Jung, Eui-Gil, Moore, Michael, Seo, Jong Bok, Kim, Yong-Hwan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519168/ https://www.ncbi.nlm.nih.gov/pubmed/32887693 http://dx.doi.org/10.1523/ENEURO.0134-20.2020 |
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