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ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer

Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as “locally...

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Autores principales: Calvo, Felipe A., Sole, Claudio V., Rutten, Harm J., Poortmans, Philip, Asencio, Jose M., Serrano, Javier, Aristu, Javier, Roeder, Falk, Dries, Wim J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519207/
https://www.ncbi.nlm.nih.gov/pubmed/33005755
http://dx.doi.org/10.1016/j.ctro.2020.09.001
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author Calvo, Felipe A.
Sole, Claudio V.
Rutten, Harm J.
Poortmans, Philip
Asencio, Jose M.
Serrano, Javier
Aristu, Javier
Roeder, Falk
Dries, Wim J
author_facet Calvo, Felipe A.
Sole, Claudio V.
Rutten, Harm J.
Poortmans, Philip
Asencio, Jose M.
Serrano, Javier
Aristu, Javier
Roeder, Falk
Dries, Wim J
author_sort Calvo, Felipe A.
collection PubMed
description Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as “locally advanced”, there is also variability in the extent of disease with no uniform definition of resectability. A practice-oriented definition of a locally advanced tumour is a tumour that cannot be resected without leaving microscopic or gross residual disease at the resection site. Since these patients do poorly with surgery alone, irradiation and chemotherapy have been added to improve the outcome. Intraoperative irradiation (IORT) is a component of local treatment intensification with favourable results in this subgroup of patients. International guidelines (National Comprehensive Cancer Network (NCCN) guidelines) currently recommend the use of IORT for rectal cancer resectable with very close or positive margins, especially for T4 and recurrent cancers. We report the ESTRO-ACROP (European Society for Radiotherapy and Oncology - Advisory Committee on Radiation Oncology Practice) recommendations for performing IORT in primary locally advanced rectal cancer.
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spelling pubmed-75192072020-09-30 ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer Calvo, Felipe A. Sole, Claudio V. Rutten, Harm J. Poortmans, Philip Asencio, Jose M. Serrano, Javier Aristu, Javier Roeder, Falk Dries, Wim J Clin Transl Radiat Oncol Article Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as “locally advanced”, there is also variability in the extent of disease with no uniform definition of resectability. A practice-oriented definition of a locally advanced tumour is a tumour that cannot be resected without leaving microscopic or gross residual disease at the resection site. Since these patients do poorly with surgery alone, irradiation and chemotherapy have been added to improve the outcome. Intraoperative irradiation (IORT) is a component of local treatment intensification with favourable results in this subgroup of patients. International guidelines (National Comprehensive Cancer Network (NCCN) guidelines) currently recommend the use of IORT for rectal cancer resectable with very close or positive margins, especially for T4 and recurrent cancers. We report the ESTRO-ACROP (European Society for Radiotherapy and Oncology - Advisory Committee on Radiation Oncology Practice) recommendations for performing IORT in primary locally advanced rectal cancer. Elsevier 2020-09-11 /pmc/articles/PMC7519207/ /pubmed/33005755 http://dx.doi.org/10.1016/j.ctro.2020.09.001 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Calvo, Felipe A.
Sole, Claudio V.
Rutten, Harm J.
Poortmans, Philip
Asencio, Jose M.
Serrano, Javier
Aristu, Javier
Roeder, Falk
Dries, Wim J
ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title_full ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title_fullStr ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title_full_unstemmed ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title_short ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
title_sort estro/acrop iort recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519207/
https://www.ncbi.nlm.nih.gov/pubmed/33005755
http://dx.doi.org/10.1016/j.ctro.2020.09.001
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