CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages

Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for microglia depletion, with the assumption that it does not affect peripheral immune cells. Here, we show that CSF1R inhibition by PLX5622 indeed affects the myeloid and lymphoid compartments, causes long-term ch...

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Detalles Bibliográficos
Autores principales: Lei, Fengyang, Cui, Naiwen, Zhou, Chengxin, Chodosh, James, Vavvas, Demetrios G., Paschalis, Eleftherios I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519218/
https://www.ncbi.nlm.nih.gov/pubmed/32900927
http://dx.doi.org/10.1073/pnas.1922788117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519218/
https://www.ncbi.nlm.nih.gov/pubmed/32900927
http://dx.doi.org/10.1073/pnas.1922788117

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