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Dynamic PB2-E627K substitution of influenza H7N9 virus indicates the in vivo genetic tuning and rapid host adaptation

Avian-origin influenza viruses overcome the bottleneck of the interspecies barrier and infect humans through the evolution of variants toward more efficient replication in mammals. The dynamic adaptation of the genetic substitutions and the correlation with the virulence of avian-origin influenza vi...

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Detalles Bibliográficos
Autores principales:	Liu, William J., Li, Jun, Zou, Rongrong, Pan, Jingcao, Jin, Tao, Li, Liqiang, Liu, Peipei, Zhao, Yingze, Yu, Xinfen, Wang, Haoqiu, Liu, Guang, Jiang, Hui, Bi, Yuhai, Liu, Lei, Yuen, Kwok-Yung, Liu, Yingxia, Gao, George F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519270/ https://www.ncbi.nlm.nih.gov/pubmed/32873642 http://dx.doi.org/10.1073/pnas.2013267117

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