Cargando…

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions

Trinucleotide repeat (TNR) expansions cause nearly 20 severe human neurological diseases which are currently untreatable. For some of these diseases, ongoing somatic expansions accelerate disease progression and may influence age of onset. This new knowledge emphasizes the importance of understandin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Gregory M., Paschalis, Vasileios, Ortega, Janice, Muskett, Frederick W., Hodgkinson, James T., Li, Guo-Min, Schwabe, John W. R., Lahue, Robert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519323/ https://www.ncbi.nlm.nih.gov/pubmed/32900932 http://dx.doi.org/10.1073/pnas.2013223117

Ejemplares similares

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
por: Gannon, Anne-Marie M., et al.
Publicado: (2012)

Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
por: Ortega, Janice, et al.
Publicado: (2021)

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
por: Keogh, Norma, et al.
Publicado: (2017)

The mismatch repair system (mutS and mutL) in Acinetobacter baylyi ADP1
por: Zhou, Hua, et al.
Publicado: (2020)

New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side
por: Lahue, Robert S.
Publicado: (2020)

DNA Repair and DNA Triplet Repeat Expansion: The Impact of Abasic Lesions on Triplet Repeat DNA Energetics
por: Völker, Jens, et al.
Publicado: (2009)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
por: Dhar, Alok, et al.
Publicado: (2008)

8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα
por: Macpherson, Peter, et al.
Publicado: (2005)

8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα
por: Macpherson, Peter, et al.
Publicado: (2005)

Characterisation of the MutS and MutL Proteins from the Pseudomonas avellanae Mismatch Repair (MMR) System
por: Grenga, Lucia, et al.
Publicado: (2012)

MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair
por: Yang, Xiao-Wen, et al.
Publicado: (2022)

A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
por: Zhao, Xiao-Nan, et al.
Publicado: (2016)

Dynamics of MutS–Mismatched DNA Complexes Are Predictive of Their Repair Phenotypes
por: DeRocco, Vanessa C., et al.
Publicado: (2014)

SLX4 dampens MutSα-dependent mismatch repair
por: Guervilly, Jean-Hugues, et al.
Publicado: (2022)

The UvrD helicase and its modulation by the mismatch repair protein MutL
por: Matson, Steven W., et al.
Publicado: (2006)

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions
por: Richard, Guy-Franck
Publicado: (2021)

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
por: LeBlanc, Sharonda J, et al.
Publicado: (2018)

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
por: Halabi, Anasheh, et al.
Publicado: (2018)

The Role of the Immune System in Triplet Repeat Expansion Diseases
por: Olejniczak, Marta, et al.
Publicado: (2015)

The 26S proteasome drives trinucleotide repeat expansions
por: Concannon, Claire, et al.
Publicado: (2013)

MutSα maintains the mismatch repair capability by inhibiting PCNA unloading
por: Kawasoe, Yoshitaka, et al.
Publicado: (2016)

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
por: Liu, Yiyong, et al.
Publicado: (2010)

Both hMutSα and hMutSß DNA Mismatch Repair Complexes Participate in 5-Fluorouracil Cytotoxicity
por: Tajima, Akihiro, et al.
Publicado: (2011)

Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells
por: Nakatani, Rie, et al.
Publicado: (2015)

Vascular histone deacetylation by pharmacological HDAC inhibition
por: Rafehi, Haloom, et al.
Publicado: (2014)

Trinucleotide repeat expansions catalyzed by human cell-free extracts
por: Stevens, Jennifer R, et al.
Publicado: (2013)

MutS Switches Between Two Fundamentally Distinct Clamps during Mismatch Repair
por: Jeong, Cherlhyun, et al.
Publicado: (2011)

Dynamic DNA Energy Landscapes and Substrate Complexity in Triplet Repeat Expansion and DNA Repair
por: Völker, Jens, et al.
Publicado: (2019)

Genome-wide contributions of the MutSα- and MutSβ-dependent DNA mismatch repair pathways to the maintenance of genetic stability in Saccharomyces cerevisiae
por: Kadyrova, Lyudmila Y., et al.
Publicado: (2023)

Electrochemical detection of mismatched DNA using a MutS probe
por: Cho, Minseon, et al.
Publicado: (2006)

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS
por: Lebbink, Joyce H. G., et al.
Publicado: (2010)

MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair
por: Liu, Jiaquan, et al.
Publicado: (2019)

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination
por: Arlow, Tim, et al.
Publicado: (2021)

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis
por: Wang, Tao, et al.
Publicado: (2022)

Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
por: Plotz, Guido, et al.
Publicado: (2006)

Statistical Enrichment of Epigenetic States Around Triplet Repeats that Can Undergo Expansions
por: Essebier, Alexandra, et al.
Publicado: (2016)

PCNA–MutSα-mediated binding of MutLα to replicative DNA with mismatched bases to induce apoptosis in human cells
por: Hidaka, Masumi, et al.
Publicado: (2005)

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS
por: Monti, Maria Chiara, et al.
Publicado: (2011)

Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6
por: Vanaja, G. R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p3g84pc49vq9e9lbfdk6o7h04m