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Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning

Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goal-directed and later automatic stages of motor sk...

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Detalles Bibliográficos
Autores principales: Choi, Yera, Shin, Emily Yunha, Kim, Sungshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519330/
https://www.ncbi.nlm.nih.gov/pubmed/32900934
http://dx.doi.org/10.1073/pnas.2003963117
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author Choi, Yera
Shin, Emily Yunha
Kim, Sungshin
author_facet Choi, Yera
Shin, Emily Yunha
Kim, Sungshin
author_sort Choi, Yera
collection PubMed
description Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goal-directed and later automatic stages of motor skill learning, respectively. However, the involvement of these circuits has not been well elucidated in human de novomotor skill learning, which requires learning arbitrary action–outcome associations and value-based action selection. To investigate this issue, we conducted a human functional MRI (fMRI) experiment in which participants learned to control a computer cursor by manipulating their right fingers. We discovered a double dissociation of fMRI activity in the anterior and posterior caudate nucleus, which was associated with performance in the early and late learning stages. Moreover, cognitive and sensorimotor cortico-caudate interactions predicted individual learning performance. Our results suggest parallel cortico-caudate networks operating in different stages of human de novomotor skill learning.
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spelling pubmed-75193302020-10-07 Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning Choi, Yera Shin, Emily Yunha Kim, Sungshin Proc Natl Acad Sci U S A Biological Sciences Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goal-directed and later automatic stages of motor skill learning, respectively. However, the involvement of these circuits has not been well elucidated in human de novomotor skill learning, which requires learning arbitrary action–outcome associations and value-based action selection. To investigate this issue, we conducted a human functional MRI (fMRI) experiment in which participants learned to control a computer cursor by manipulating their right fingers. We discovered a double dissociation of fMRI activity in the anterior and posterior caudate nucleus, which was associated with performance in the early and late learning stages. Moreover, cognitive and sensorimotor cortico-caudate interactions predicted individual learning performance. Our results suggest parallel cortico-caudate networks operating in different stages of human de novomotor skill learning. National Academy of Sciences 2020-09-22 2020-09-08 /pmc/articles/PMC7519330/ /pubmed/32900934 http://dx.doi.org/10.1073/pnas.2003963117 Text en Copyright © 2020 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Choi, Yera
Shin, Emily Yunha
Kim, Sungshin
Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title_full Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title_fullStr Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title_full_unstemmed Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title_short Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
title_sort spatiotemporal dissociation of fmri activity in the caudate nucleus underlies human de novo motor skill learning
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519330/
https://www.ncbi.nlm.nih.gov/pubmed/32900934
http://dx.doi.org/10.1073/pnas.2003963117
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