Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). A potent Nef inhibitor that restores MHC-I is needed to promote immune-mediated clearance of HIV-infected cel...

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Detalles Bibliográficos
Autores principales: Painter, Mark M., Zimmerman, Gretchen E., Merlino, Madeline S., Robertson, Andrew W., Terry, Valeri H., Ren, Xuefeng, McLeod, Megan R., Gomez-Rodriguez, Lyanne, Garcia, Kirsten A., Leonard, Jolie A., Leopold, Kay E., Neevel, Andrew J., Lubow, Jay, Olson, Eli, Piechocka-Trocha, Alicja, Collins, David R., Tripathi, Ashootosh, Raghavan, Malini, Walker, Bruce D., Hurley, James H., Sherman, David H., Collins, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519347/
https://www.ncbi.nlm.nih.gov/pubmed/32900948
http://dx.doi.org/10.1073/pnas.2008615117

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